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Mapping Trajectories of Alzheimer's Progression via Personalized Brain Anchor-nodes

Award Number: R01AG075582
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/15/2022
PERIOD OF PERFORMANCE END DATE: 01/31/2027

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Mapping Trajectories of Alzheimer's Progression via Personalized Brain Anchor-nodes - Project Summary Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disorder, not only in pathophysiology, but also at different disease progression stages. Despite numerous studies that have investigated the clinical utility of magnetic resonance imaging (MRI) based biomarkers in characterizing AD stages from asymptomatic to mildly symptomatic to dementia, making a personalized precision prediction and early diagnosis of AD is still challenging. Existing imaging biomarkers are limited in representing significant heterogeneity across different individuals and at different clinical stages. This challenge originates from the lack of reliable brain landmarks that can simultaneously characterize and represent robust population correspondences and individual variation during normal aging and AD progression. In response, this project aims to: 1) Identify a set of brain anchor- nodes as population landmarks based on both group-wise consistent patterns and individualized anatomical and connectivity properties during normal aging and AD progression among massive, publicly available neuroimaging data sources; 2) Develop an efficient individualized shape transformation approach based on deep learning to map population anchor-nodes to individual brains by flexibly leveraging multimodal individual features; and 3) Construct a progression tree using anchor-nodes derived brain measures to unveil and represent the wide spectrum of AD development. Individual subjects can thus be projected to the tree structure to effectively and conveniently access their clinical status and predict the trend of AD progression. We will test our new frameworks on four large independent aging/AD cohorts including HCP-Aging, UK Biobank, ADNI and the latest stage of Open Access Series of Imaging Studies (OASIS-3), and freely release our computational tools and processed data to the public.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $532,067 )
2025	2025	UNIVERSITY OF TEXAS AT ARLINGTON	701 S NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Aging Research	000	4	1/13/2025	NON-COMPETING CONTINUATION	$488,633
2025	2025	UNIVERSITY OF TEXAS AT ARLINGTON	701 S NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Aging Research	001	4	8/12/2025	NON-COMPETING CONTINUATION	$43,434
														Subtotal = $532,067

Issue Date FY: 2024 ( Subtotal = $542,925 )
2024	2024	THE UNIVERSITY OF TEXAS AT ARLINGTON	701 S. NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Aging Research	000	3	2/1/2024	NON-COMPETING CONTINUATION	$488,633
2024	2024	UNIVERSITY OF TEXAS AT ARLINGTON	701 S NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Aging Research	001	3	6/25/2024	NON-COMPETING CONTINUATION	$54,292
														Subtotal = $542,925

Issue Date FY: 2023 ( Subtotal = $546,775 )
2023	2023	THE UNIVERSITY OF TEXAS AT ARLINGTON	701 S. NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Aging Research	000	2	2/3/2023	NON-COMPETING CONTINUATION	$546,775
														Subtotal = $546,775

Issue Date FY: 2022 ( Subtotal = $609,920 )
2022	2022	UNIVERSITY OF TEXAS AT ARLINGTON	400 S CORN ST	ARLINGTON	TX	76019	TARRANT	USA	Aging Research	000	1	2/14/2022	NEW	$609,920
														Subtotal = $609,920

Grand Total All Awards = $2,231,687

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Mapping Trajectories of Alzheimer's Progression via Personalized Brain Anchor-nodes

Award Number: R01AG075582

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/15/2022

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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