Wednesday, September 17, 2025 9/17/2025

High-dimensional Modeling of PET for radiomic Biomarker Discovery

Award Number: R01AG075511
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2027

Group Awards By:

View Award Description

High-dimensional Modeling of PET for radiomic Biomarker Discovery - Project Summary We propose to develop statistical methods for the analysis of longitudinal positron emission tomography (PET) data for patients with Alzheimer’s disease (AD). Disease biomarkers identified from PET data are necessary for integrating these imaging modalities in observational studies and in clinical trials for drug development for AD. We propose statistical methods for the analysis of PET images including dimension reduction and biomarker extraction from voxel-wise intensity analysis that incorporate disease progression in two observational studies including data on early-onset and late-onset AD participants. Our methods allow for integration of MRI atrophy measures in the analyses to obtain multimodal predictors of disease severity and progression. The proposed methods will utilize the complex data and noise structure for developing powerful tools for biomarker identification that can be used for finding differences of disease progression between populations of interest. Particularly, our proposed biomarkers incorporate information on shape and texture of radiological images for prediction. The proposed methods can be incorporated to analyze data in future studies in most AD data collection centers as well as to apply in radiomics of imaging data in general.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $654,860 )
2025	2025	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Aging Research	000	4	7/3/2025	NON-COMPETING CONTINUATION	$654,860
														Subtotal = $654,860

Issue Date FY: 2024 ( Subtotal = $668,225 )
2024	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Aging Research	000	3	5/14/2024	NON-COMPETING CONTINUATION	$668,225
														Subtotal = $668,225

Issue Date FY: 2023 ( Subtotal = $709,068 )
2023	2023	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Aging Research	000	2	6/30/2023	NON-COMPETING CONTINUATION	$709,068
														Subtotal = $709,068

Issue Date FY: 2022 ( Subtotal = $723,943 )
2022	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Aging Research	000	1	8/18/2022	NEW	$723,943
														Subtotal = $723,943

Grand Total All Awards = $2,756,096

Top

All Categories

About

Search

Reports

Data Submission

Award Information

High-dimensional Modeling of PET for radiomic Biomarker Discovery

Award Number: R01AG075511

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer