Tuesday, April 23, 2024 4/23/2024

Passive heat therapy for lowering systolic blood pressure and improving vascular function in mid-life and older adults

Award Number: R01AG073117
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Aging is the primary risk factor for Alzheimer’s disease and related dementias, as well as mild cognitive impairment (MCI). Above-normal systolic blood pressure (SBP; =120 mmHg) further increases risk of dementias, due, in part, to SBP-associated cerebrovascular dysfunction, i.e., impaired cerebral blood flow regulation. Accordingly, midlife and older adults with above-normal SBP are at the highest risk for cognitive decline driven by vascular contributions to cognitive impairment and dementias in this age group. Excessive reactive oxygen species-induced oxidative stress and reductions in nitric oxide (NO) bioavailability within the cerebral vasculature likely mediate cerebrovascular dysfunction with aging and contribute to MCI and Alzheimer’s disease and related dementias in those with above-normal SBP. Passive heat therapy (regular short-term increases in body core temperature) is an established lifestyle practice in certain cultures (e.g., sauna bathing in Finland; hot spring bathing in Japan) and may be effective for decreasing risk of dementias. Epidemiological research suggests regular sauna use is associated with ~65% lower incidence of dementias, supporting heat therapy as a powerful candidate approach to significantly reduce risk of dementias. However, randomized controlled trials are urgently needed to establish the causal link between passive heat therapy and risk factors for MCI, Alzheimer’s disease and related dementias. Results from our pilot trial show that 8-10 weeks of heat therapy (hot water immersion 3x1 h/week) lowered SBP (-10 mmHg) and improved cognitive performance and cerebrovascular function vs. sham (thermoneutral water immersion). Heat therapy also reduced vascular markers of oxidative stress and increased NO bioavailability. Our parent award is a randomized clinical trial assessing 3 months (36 x 1 h sessions) of passive heat therapy vs. sham immersion for lowering SBP and improving peripheral vascular function in midlife and older adults with SBP 120-139 mmHg. This proposal will extend the work of our parent grant by assessing the efficacy of heat therapy for: 1) increasing key domains of cognitive performance; 2) improving cerebrovascular blood flow and other measures of cerebrovascular function and health that are closely linked to MCI and dementias; and 3) decreasing oxidative stress and increasing NO-bioavailability, important mechanisms likely underlying cognitive impairment and dementias. This research is highly relevant to MCI and Alzheimer’s disease and related dementias, as it will evaluate a novel lifestyle-based therapy for improving key risk factors for these disorders. Leveraging our existing clinical trial, we will provide the first evidence for the efficacy of passive heat therapy for enhancing cognitive and cerebrovascular function in older adults at risk of developing MCI and Alzheimer’s disease and related dementias. Lastly, the proposed research will also stimulate future research promoting translation of this promising lifestyle intervention to other at-risk groups.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	THE REGENTS OF THE UNIVERSITY OF COLORADO	3100 MARINE ST	BOULDER	CO	80309	BOULDER	USA	Aging Research	001	2	3/26/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	THE REGENTS OF THE UNIVERSITY OF COLORADO	3100 MARINE ST	BOULDER	CO	80309	BOULDER	USA	Aging Research	000	2	3/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $1,004,633 )
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	3100 MARINE ST STE 481 572 UCB	BOULDER	CO	80309	BOULDER	USA	Aging Research	001	2	5/11/2023	SUPPLEMENT FOR EXPANSION	$375,588
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	3100 MARINE ST STE 481 572 UCB	BOULDER	CO	80309	BOULDER	USA	Aging Research	000	2	5/5/2023	NON-COMPETING CONTINUATION	$629,045
														Subtotal = $1,004,633

Issue Date FY: 2022 ( Subtotal = $654,978 )
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	3100 MARINE ST STE 481 572 UCB	BOULDER	CO	80309	BOULDER	USA	Aging Research	000	1	3/23/2022	NEW	$654,978
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	3100 MARINE ST STE 481 572 UCB	BOULDER	CO	80309	BOULDER	USA	Aging Research	001	1	8/2/2022	NEW	$0
														Subtotal = $654,978

Grand Total All Awards = $1,659,611

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Passive heat therapy for lowering systolic blood pressure and improving vascular function in mid-life and older adults

Award Number: R01AG073117

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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