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A Study of Race Differences in Alzheimer's Disease Biomarkers

Award Number: R01AG072760
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2021
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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A Study of Race Differences in Alzheimer's Disease Biomarkers - Abstract We propose to combine mass spectrometry and machine learning to address racial disparities in Alzheimer's disease (AD) research. While African Americans have two to three times the incidence rates of AD than people of European Ancestry, they are underrepresented in past and current AD research studies. The lack of representation leads to a weaker understanding of disease progression and poorer diagnostics for this population. The overarching premise, that advances in diagnosing and treating Alzheimer's disease for all Americans will be stymied unless differences among racial groups are considered, is supported by the literature and demonstrated with preliminary data in the application. The aims of this proposal are, therefore, designed to specifically address the need for a better understanding of Alzheimer's disease in minority groups and to increase the diversity of patients that could be correctly diagnosed with serum-based biomarker panels for AD. Successful completion of the proposed research would accomplish several objectives: We would identify optimal feature selection methods for `omics data; generate the best possible plasma biomarker panel for AD in African Americans; and provide a systematic investigation of the extent to which existing MS- `omics studies' accuracy of predicting AD are modulated by the participants' race.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $335,272 )
2025	2025	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Aging Research	001	3	6/4/2025	NON-COMPETING CONTINUATION	$335,262
2025	2024	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Aging Research	000	2	10/15/2024	EXTENSION WITH OR WITHOUT FUNDS	$10
														Subtotal = $335,272

Issue Date FY: 2024 ( Subtotal = $349,885 )
2024	2024	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Aging Research	000	2	6/27/2024	EXTENSION WITH OR WITHOUT FUNDS	$349,885
														Subtotal = $349,885

Grand Total All Awards = $685,157

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A Study of Race Differences in Alzheimer's Disease Biomarkers

Award Number: R01AG072760

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2021

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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