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Social Convoys, Cognitive Reserve and Resilience, and Risk for Alzheimer's Disease and Related Dementias

Award Number: R01AG069041
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2020
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Social Convoys, Cognitive Reserve and Resilience, and Risk for Alzheimer's Disease and Related Dementias - 7. PROJECT SUMMARY/ABSTRACT Emerging evidence suggests that sexual and gender minority populations are at increased risk for Alzheimer’s disease and related dementias (ADRD). This may be due, at least in part, to the cumulative impact of minority stress;; related social isolation and loneliness;; and barriers to care and support services. Social support, on the other hand, has emerged as a protective factor in the face of minority stress, and as a predictor of successful cognitive aging among the general population. However, few studies have assessed the social support networks of sexual and gender minorities in detail to determine the specific support characteristics that facilitate cognitive reserve and resilience. The proposed study will fill this gap by comparing the stress, social support networks, and aging-related cognition of a newly recruited sample of sexual and gender minority adults (n = 300, age 25- 85) to those of a matched heterosexual, cisgender sample (n = 300) enrolled in an ongoing longitudinal study of aging and cognitive reserve (the Reference Ability Neural Networks or RANN study). In addition, the proposed study will conduct secondary analysis of MRI data collected in RANN to explore differences in brain features between minority and majority groups, generating hypotheses for future research. The specific aims are: (1) To compare stress (perceived general stress and minority stress related to one or more marginalized identities) and cognitive performance across multiple domains in newly recruited sexual / gender minority adults and matched heterosexual, cisgender adults enrolled in the RANN study;; (2) To compare social network characteristics of sexual / gender minority adults to those of matched heterosexual, cisgender adults, and examine within- and between-group differences in social support based on sexual orientation, gender identity, and age;; (3) Across both identity groups (N = 600), to examine the role of minority stress, social support, resources and wellbeing in development of cognitive reserve and resilience (i.e., how these assets moderate the effects of minority stress and aging on health and cognitive functioning);; and (4) In an exploratory analysis, to evaluate differences between sexual / gender minority (n > 40) and matched heterosexual, cisgender RANN participants in MRI- measured brain features and their relation to stress, social network characteristics, cognitive functioning, and risk for incident ADRD. We expect that understanding differences and similarities in the social networks of minority and majority adults and the relationship of these characteristics to stress and aging-related cognition will enable us to identify modifiable factors associated with cognitive reserve and resilience, informing future interventions to prevent cognitive decline and ADRD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $634,712 )
2025	2025	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Aging Research	002	5	8/8/2025	NON-COMPETING CONTINUATION	$634,712
2025	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Aging Research	001	4	7/7/2025	NON-COMPETING CONTINUATION	$0
2025	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Aging Research	000	4	3/24/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $634,712

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Aging Research	000	4	6/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $765,460 )
2023	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Aging Research	000	4	5/22/2023	NON-COMPETING CONTINUATION	$765,460
2023	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Aging Research	001	4	8/18/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $765,460

Issue Date FY: 2022 ( Subtotal = $765,460 )
2022	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Aging Research	000	3	7/8/2022	NON-COMPETING CONTINUATION	$765,460
														Subtotal = $765,460

Issue Date FY: 2021 ( Subtotal = $768,642 )
2021	2021	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Aging Research	001	2	6/17/2021	NON-COMPETING CONTINUATION	$768,642
2021	2020	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Aging Research	000	1	5/28/2021	NEW	$0
														Subtotal = $768,642

Issue Date FY: 2020 ( Subtotal = $808,619 )
2020	2020	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Aging Research	000	1	9/8/2020	NEW	$808,619
														Subtotal = $808,619

Grand Total All Awards = $3,742,893

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Social Convoys, Cognitive Reserve and Resilience, and Risk for Alzheimer's Disease and Related Dementias

Award Number: R01AG069041

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2020

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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