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Microbiome and immunosenescence ofÂ T cells repertoire

Award Number: R01AG068875
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2020
PERIOD OF PERFORMANCE END DATE: 04/30/2025

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Microbiome and immunosenescence ofÂ T cells repertoire - The intestinal microbiota is a major contributor of antigens recognized by intestinal CD4 T cells. How these antigens influence CD4 T cells immunosenescence and their effector functions in old mice and humans remains unclear. Therefore, there is a need to develop a standardized microbial flora that has a manageable size and resembles natural microbiome that when administered to old, frail individuals will rebalance their intestinal homeostasis. The goal of this proposal is to test if this new oligoclonal collection of mouse intestinal commensals (oligo-MM), designed by system and genome-based approaches to recapitulate complete microbiome can help revitalize an aging immune system. In particular, we will investigate how oligo-MM microbiota and its main component Akkermasia municiphila interacts with Cd4 T cells and discover immune epitopes that these cells recognize from this bacteria. In Aim 1 we will investigate how specific intestinal commensals influence activation and repertoire of CD4 T cells in old mice. In our Aim 2 we will demonstrate that A. municiphila derived antigens induce naïve CD4Foxp3- T cells conversion to CD4Foxp3+ pTregs and substantially increase the number of these cells in old mice. We hypothesize that the therapeutic administration of A. municiphila to old mice can improve tolerance to intestinal microbiota and reduce immunosenescence. Overall this research will help develop new strategies based on strictly controlled microbiota-based therapies to control intestinal inflammation in elderly.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $390,000 )
2024	2024	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Aging Research	000	5	7/11/2024	NON-COMPETING CONTINUATION	$390,000
														Subtotal = $390,000

Issue Date FY: 2023 ( Subtotal = $390,000 )
2023	2023	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Aging Research	000	4	5/2/2023	NON-COMPETING CONTINUATION	$390,000
														Subtotal = $390,000

Issue Date FY: 2022 ( Subtotal = $390,000 )
2022	2022	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Aging Research	000	3	7/7/2022	NON-COMPETING CONTINUATION	$390,000
														Subtotal = $390,000

Issue Date FY: 2021 ( Subtotal = $389,791 )
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Aging Research	000	2	6/3/2021	NON-COMPETING CONTINUATION	$389,791
														Subtotal = $389,791

Issue Date FY: 2020 ( Subtotal = $388,750 )
2020	2020	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Aging Research	000	1	9/9/2020	NEW	$388,750
														Subtotal = $388,750

Grand Total All Awards = $1,948,541

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Microbiome and immunosenescence ofÂ T cells repertoire

Award Number: R01AG068875

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2020

PERIOD OF PERFORMANCE END DATE: 04/30/2025

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