Monday, December 30, 2024 12/30/2024

Harnessing Single Cell Epigenome-wide profiling of Myeloid cells to Compare and Contrast Alzheimer's from HIV-Associated Cognitive Dysfunction

Award Number: R01AG063846
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ ABSTRACT (for Nicholas Hampilos (Ndhlovu): R01 AG063846-01A1 Supplement Application) In this application, we seek a diversity research supplement to the parent award “HARNESSING CELL ALZHEIMER'S SINGLE EPIGENOME-WIDE PROFILING OF MYELOID CELLS TO COMPARE AND CONTRAST FROM HIV-ASSOCIATED COGNITIVE DYSFUNCTION” (AG063846). The parent award seeks to define the epigenomic landscape of myeloid populations in order to differentiate HIV Associated Neurocognitive Disease (HAND) from Mild Cognitive Impairment state of Alzheimer's Disease (MCI-AD) in individuals living with HIV on suppressive antiretroviral therapy (ART). This diversity supplement will expand the scope of research in Specific Aim 2 by enabling the addition of cellular immunophenotyping and MRI and proton magnetic resonance spectroscopy (1H MRS) imaging in 5 subjects with HAND and 5 cognitively normal subjects with HIV from the parent study, with plans to include subjects with MCI-AD in the future if additional funding is secured. The main aims of the supplemental research project are 1) to investigate the neurobiochemical features that may distinguish people living with HIV (PLWH) with HAND versus those without HAND by measuring neurometabolites in the basal ganglia with 1H MRS and 2) to explore possible relationships between neurometabolite levels and monocyte counts and phenotypes by linear regression. With respect to the first aim, our hypothesis is that PLWH with HAND will have lower levels of both GSH and NAA in the basal ganglia compared to PWLH without HAND, reflecting oxidative stress and greater neuronal injury, respectively. We also hypothesize that total and intermediate type monocyte counts as well as CCR2 and CD163 surface expression levels will be inversely correlated with GSH and NAA levels in PLWH, which would further support monocytes being drivers of neuropathology in PLWH. In addition to funding a supplemental research project, the NIA diversity supplement would provide a plethora of mentoring, training, and educational opportunities to Dr. Hampilos at a critical point in his career. More specifically, the diversity supplement would enable Dr. Hampilos to: 1) gain clinical and laboratory research experience in geriatric Neuro HIV and cellular immunology through mentoring, coursework and “hands-on” training in immunophenotyping of peripheral monocytes, which will be required for the proposed supplemental research project, 2) reinforce his radiology training, by enabling Dr. Hampilos to analyze and interpret MRI and 1H MRS results, 3) provide opportunities to enhance his presentation, writing skills, and grantsmanship and 4) generate key preliminary data which would be used to apply for an NIA K22 Career Transition Award and an award from a private foundation in 2024 and/or 2025.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $945,668 )
2024	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Aging Research	004	5	7/2/2024	SUPPLEMENT FOR EXPANSION	$6,302
2024	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Aging Research	001	5	3/1/2024	SUPPLEMENT FOR EXPANSION	$56,715
2024	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Aging Research	003	5	7/1/2024	NON-COMPETING CONTINUATION	$78,364
2024	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Aging Research	000	5	2/27/2024	NON-COMPETING CONTINUATION	$705,275
2024	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Aging Research	002	5	3/19/2024	SUPPLEMENT FOR EXPANSION	$99,012
														Subtotal = $945,668

Issue Date FY: 2023 ( Subtotal = $921,890 )
2023	2023	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Aging Research	000	4	3/2/2023	NON-COMPETING CONTINUATION	$795,857
2023	2023	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Aging Research	001	4	3/6/2023	SUPPLEMENT FOR EXPANSION	$126,033
														Subtotal = $921,890

Issue Date FY: 2022 ( Subtotal = $870,630 )
2022	2022	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Aging Research	000	3	2/9/2022	NON-COMPETING CONTINUATION	$726,849
2022	2022	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Aging Research	001	3	6/13/2022	NON-COMPETING CONTINUATION	$80,764
2022	2022	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Aging Research	002	3	8/12/2022	SUPPLEMENT FOR EXPANSION	$63,017
														Subtotal = $870,630

Issue Date FY: 2021 ( Subtotal = $819,055 )
2021	2021	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Aging Research	000	2	3/17/2021	NON-COMPETING CONTINUATION	$819,055
														Subtotal = $819,055

Issue Date FY: 2020 ( Subtotal = $863,930 )
2020	2020	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	407 E 61ST ST RM 106 1ST FL	NEW YORK	NY	10065	NEW YORK	USA	Aging Research	000	1	3/10/2020	NEW	$863,930
														Subtotal = $863,930

Grand Total All Awards = $4,421,173

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Harnessing Single Cell Epigenome-wide profiling of Myeloid cells to Compare and Contrast Alzheimer's from HIV-Associated Cognitive Dysfunction

Award Number: R01AG063846

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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