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Olfactory and Visual Dysfunction as Potential Predictors of Preclinical Alzheimer's Disease

Award Number: R01AG062006
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2018
PERIOD OF PERFORMANCE END DATE: 11/30/2025

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Olfactory and Visual Dysfunction as Potential Predictors of Preclinical Alzheimer's Disease - Simple odor identification tests reveal reduced ability to identify odors in Alzheimer's disease (AD) and in populations at risk for AD because of the ApoE e4 allele, MCI, and a family history of AD. Neuropathology in olfactory areas in AD is well established in post-mortem tissue and in a few structural MRI studies. While impairment in olfaction is known to occur in AD and in those at risk for AD, its sensitivity and specificity, based on simple odor identification tests, has not been sufficient to render it a serious biomarker. Critical research is needed to test the sensitivity of impairment in the olfactory system to signal risk for AD. This will require careful consideration of the methods for testing olfactory system integrity that go beyond simple odor identification tests. Similarly, there is significant evidence to support a difference in retinal thinning between normally aging individuals AD; however whether this measure is predictive of development of MCI or AD in amyloid positive, cognitively normal individuals in unknown. There is a clear need to investigate whether assessment of multiple sensory modalities in conjunction with CSF and imaging markers will improve the detection of preclinical AD. This project aims to address this need using a multimodal approach. It will investigate whether olfactory or visual function or a combination better reflects the presence of CSF biomarkers or structural MRI markers of AD in preclinical AD. Building on a foundation of preliminary data, the project will investigate the underlying cortical structures and neural networks that serve odor recognition memory, remote odor memory and odor identification in individuals with CSF markers that reflect preclinical AD, using fMRI and functional connectivity. The project will develop a deeper understanding of the potential for sensory dysfunction to predict preclinical AD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR	SAN DIEGO	CA	92182	SAN DIEGO	USA	Aging Research	000	5	11/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $576,019 )
2023	2023	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Aging Research	000	5	1/5/2023	NON-COMPETING CONTINUATION	$576,019
														Subtotal = $576,019

Issue Date FY: 2022 ( Subtotal = $576,019 )
2022	2022	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Aging Research	001	4	4/22/2022	NON-COMPETING CONTINUATION	$57,601
2022	2022	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Aging Research	000	4	12/3/2021	NON-COMPETING CONTINUATION	$518,418
														Subtotal = $576,019

Issue Date FY: 2021 ( Subtotal = $417,082 )
2021	2021	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Aging Research	000	3	12/16/2020	NON-COMPETING CONTINUATION	$375,375
2021	2021	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Aging Research	001	3	2/10/2021	NON-COMPETING CONTINUATION	$41,707
														Subtotal = $417,082

Issue Date FY: 2020 ( Subtotal = $589,615 )
2020	2020	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Aging Research	000	2	12/5/2019	NON-COMPETING CONTINUATION	$530,653
2020	2020	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Aging Research	001	2	1/30/2020	NON-COMPETING CONTINUATION	$58,962
														Subtotal = $589,615

Issue Date FY: 2019 ( Subtotal = $597,592 )
2019	2019	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Aging Research	000	1	2/16/2019	NEW	$597,592
														Subtotal = $597,592

Grand Total All Awards = $2,756,327

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Olfactory and Visual Dysfunction as Potential Predictors of Preclinical Alzheimer's Disease

Award Number: R01AG062006

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2018

PERIOD OF PERFORMANCE END DATE: 11/30/2025

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