Sunday, August 31, 2025 8/31/2025

Wisconsin longitudinal study: Initial lifetime's impact on Alzheimer's disease and related disorders (WLS-ILIAD)

Award Number: R01AG060737
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2018
PERIOD OF PERFORMANCE END DATE: 02/29/2028

Group Awards By:

View Award Description

Wisconsin longitudinal study: Initial lifetime's impact on Alzheimer's disease and related disorders (WLS-ILIAD) - Abstract The overarching scientific premise of this application is to evaluate how the accumulation of social advantage and adversity over the full life course impacts risk and resilience against Alzheimer’s Disease (AD) and Related Dementias (ADRD). While there is considerable enthusiasm across the social and biological sciences regarding the sociobiological underpinnings of multifaceted diseases, including a growing research base on the social exposome and social determinants of health, evidence clearly linking *lifetime* social exposures to AD/ADRD remains limited. Existing work has been hampered by the paucity of data that covers the full life course, and relative inattention to how sex and, especially gender, may shape these processes. We address these gaps with the competing renewal application of an NIA-funded R01 (AG06073), entitled the “Wisconsin Longitudinal Study-Initial Lifetime’s Impact on ADRD (WLS-ILIAD)”, which began tracking AD and related dementia onset in 2019 among a cohort of older adults with prospectively collected data extending to their birth year. Having achieved an ~80% response rate during the current grant cycle (2018-2023), the renewed project would continue to assess for dementia as participants surpass age 85. We propose to continue the WLS-ILIAD project to build an invaluable and uniquely comprehensive dataset, which will allow us-and our broader user base-to characterize the AD biomarkers, cognitive, social, behavioral, and medical profile of participants at risk or resilient to dementia. The specific aims for this proposal include: Aim 1: We will continue to track dementia in the WLS cohort using rigorous AD biomarkers, when participants will be ~age 85-90. As before, data will be released for broad public use. Aim 2: We will add plasma AD biomarkers to the full sample (n=~5000) to examine whether core AD biomarkers predict and moderate cognitive function, AD risk, or resilience. Amyloid and tau PET brain scans, and cerebrospinal fluid (CSF) collection will be performed on 200 participants with 100 follow up visits to validate the blood-based biomarkers and identify cut points for specific blood AD biomarkers. Aim 3. Examine how accumulated social advantage and adversity influence risk and resilience against dementia onset, with attention to sex/gender differences. This aim focuses on two forms of resilience. The first is resilience to dementia. Regardless of underlying pathology, the costs attributable to dementia are high, with global health care spending on dementia projected to reach $1.6 trillion by 2050, so attention to its determinants are critical. The second type is the absence of clinical symptoms or dementia in the presence of AD pathology as established through antemortem disease biomarkers. Aim 4: Drawing on AD biomarkers collected in Aim 2, we will fold a large sample (n=468) of African American and Indigenous participants enrolled in the Wisconsin ADRC to analyze how early life advantage and adversity impact resilience in cognitive function in the presence of AD pathology. This extends the aims of the prior grant period’s attention to early life influences on dementia risk and resilience.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $10,293,461 )
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Aging Research	002	8	8/14/2025	NON-COMPETING CONTINUATION	$0
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Aging Research	001	8	6/17/2025	NON-COMPETING CONTINUATION	$840,284
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Aging Research	000	8	3/6/2025	NON-COMPETING CONTINUATION	$9,453,177
														Subtotal = $10,293,461

Issue Date FY: 2024 ( Subtotal = $11,478,637 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Aging Research	002	7	6/28/2024	NON-COMPETING CONTINUATION	$1,147,864
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Aging Research	001	7	2/21/2024	NON-COMPETING CONTINUATION	$10,330,773
2024	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Aging Research	000	5	1/30/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $11,478,637

Issue Date FY: 2023 ( Subtotal = $11,444,831 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Aging Research	000	6	5/15/2023	COMPETING CONTINUATION	$11,444,831
														Subtotal = $11,444,831

Issue Date FY: 2022 ( Subtotal = $2,488,576 )
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Aging Research	000	5	8/31/2022	NON-COMPETING CONTINUATION	$2,488,576
														Subtotal = $2,488,576

Issue Date FY: 2021 ( Subtotal = $3,611,514 )
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	000	4	6/29/2021	NON-COMPETING CONTINUATION	$3,611,514
														Subtotal = $3,611,514

Issue Date FY: 2020 ( Subtotal = $3,921,236 )
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	003	3	8/26/2020	SUPPLEMENT FOR EXPANSION	$347,096
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	002	3	7/29/2020	NON-COMPETING CONTINUATION	$3,574,140
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	004	3	9/2/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2019	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	001	2	7/28/2020	NON-COMPETING CONTINUATION	$0
2020	2018	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	000	1	7/27/2020	NEW	$0
														Subtotal = $3,921,236

Issue Date FY: 2019 ( Subtotal = $3,262,041 )
2019	2019	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	000	2	7/10/2019	NON-COMPETING CONTINUATION	$3,262,041
														Subtotal = $3,262,041

Issue Date FY: 2018 ( Subtotal = $950,709 )
2018	2018	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	000	1	9/12/2018	NEW	$950,709
														Subtotal = $950,709

Grand Total All Awards = $47,451,005

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Wisconsin longitudinal study: Initial lifetime's impact on Alzheimer's disease and related disorders (WLS-ILIAD)

Award Number: R01AG060737

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2018

PERIOD OF PERFORMANCE END DATE: 02/29/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer