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India ENIGMA Initiative for Global Aging & Mental Health

Award Number: R01AG060610
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2019
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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India ENIGMA Initiative for Global Aging & Mental Health - ABSTRACT Our revised proposal launches the India ENIGMA Initiative for Global Aging & Mental Health - a globally coordinated study of brain aging and Alzheimer's disease (AD), created response to the NIH FOA: Global Brain and Nervous System Disorders Research Across the Lifespan (R01; PAR-18-834; https://grants.nih.gov/grants/guide/pa-files/PAR-18-835.html). Our overall goal is to identify predictive markers in the blood, genome, and epigenome that influence brain aging in India, to better understand prognosis, and to support personalized risk evaluations on each continent. We plan to identify etiological pathways to resilience using the rich biobanking strategy developed by our partners at NIMHANS in India. To do this, we will leverage our global consortium, ENIGMA (http://enigma.ini.usc.edu), to partner with dementia research pioneers in India, creating new links between international biobanks, and building research capacity. By 2020, 70% of the world's population over age 60 will live in developing countries, with 14% in India (Mathuranath 2012). Recently, attention has been drawn to a “diversity” crisis in brain research, as most brain research is conducted in Caucasian populations from relatively wealthy backgrounds (LeWinn 2017). This lack of ethnic diversity means that: (1) we do not know if predictors of health (and disease) generalize to other ethnic groups, and (2) we fail to collect vital data that could teach us how AD progresses in populations with different genetic and environmental backgrounds. Our coordinated analyses in US/EU and Indian biobanks will help identify brain aging predictors specific to India and those that are universal. Specifically, we will: Aim 1. Create Lifespan Charts of brain aging Trajectories in India using MRI, DWI and Resting State Functional MRI. Aim 2. Identify Blood and Epigenetic Markers that Predict Brain Aging and AD in India. Aim 3. Using a combination of multimodal imaging, blood markers, and clinical data to predict clinical decline in India. We test structural equation models that hypothesize how brain aging depends on lifestyle and psychosocial factors (diet, family support, drug abuse, literacy, sleep, and depression), as well as sex, education, and AD genetic risk. With novel machine learning methods, will analyze blood markers and plasma proteomic analytes, to define processes that are harmful to brain aging. In Capacity Building Aims, we will leverage ENIGMA's successful strategies to train emerging and established scientists in India to analyze their data with high quality control and precision, with targeted biostatistical and imaging workshops to bolster capacity. This collaborative India-US initiative will enable future science initiatives, and equip the NIMHANS team with the necessary tools to train new scientists and independently conduct high impact research bridging efforts into numerous international partnerships.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$360,584 )
2026	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Aging Research	001	5	12/4/2025	NON-COMPETING CONTINUATION	$0
2026	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Aging Research	000	5	11/25/2025	NON-COMPETING CONTINUATION	-$360,584
														Subtotal = -$360,584

Issue Date FY: 2024 ( Subtotal = $568,893 )
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Aging Research	000	5	8/6/2024	NON-COMPETING CONTINUATION	$568,893
														Subtotal = $568,893

Issue Date FY: 2023 ( Subtotal = $568,893 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Aging Research	000	4	7/10/2023	NON-COMPETING CONTINUATION	$568,893
														Subtotal = $568,893

Issue Date FY: 2022 ( Subtotal = $568,893 )
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	001	3	8/10/2022	NON-COMPETING CONTINUATION	$568,893
2022	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	002	2	9/2/2022	NON-COMPETING CONTINUATION	$0
2022	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	000	1	8/8/2022	NEW	$0
														Subtotal = $568,893

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	000	2	8/3/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $568,893 )
2020	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	001	2	6/9/2020	NON-COMPETING CONTINUATION	$568,893
2020	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	000	1	5/18/2020	NEW	$0
														Subtotal = $568,893

Issue Date FY: 2019 ( Subtotal = $562,938 )
2019	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	000	1	8/24/2019	NEW	$562,938
														Subtotal = $562,938

Grand Total All Awards = $2,477,926

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India ENIGMA Initiative for Global Aging & Mental Health

Award Number: R01AG060610

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2019

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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