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The role of type 2 diabetes on skeletal muscle atrophy and recovery following bed rest in older adults

Award Number: R01AG060153
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2018
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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The role of type 2 diabetes on skeletal muscle atrophy and recovery following bed rest in older adults - PROJECT SUMMARY Loss of muscle mass during periods of disuse due to illness or hospitalization and poor recovery have serious health consequences for older adults. The mechanisms underlying the atrophy response to disuse and subsequent recovery in humans, however, are not known. We posit that poor mitochondrial energetics and altered muscle lipid metabolism contribute to greater disuse- induced muscle atrophy and poor recovery. In addition, we believe that older subjects with type 2 diabetes have reduced mitochondria capacity and excess muscle lipids, which exacerbates the deleterious effect of bed rest on muscle mass and impairs recovery. Mitochondria play a fundamental role in muscle health and impaired mitochondrial energetics and muscle lipids have been shown to contribute to human aging and type 2 diabetes. The role of mitochondrial energetics in human muscle atrophy and recovery is not known. In this project, we will test the hypothesis that altered mitochondrial energetics in muscle atrophy and recovery via cardiolipin remodeling, elevated reactive oxygen species (ROS) emission and accumulation of specific muscle sphingolipids blunt anabolic stimuli and contribute to muscle atrophy and poor recovery. The overall objective of this project is to decipher mechanisms by which mitochondrial energetics and muscle lipids underlie early muscle catabolic and anabolic responses to disuse and recovery. Studying older adults with type 2 diabetes and using an exercise recovery program will provide a physiological context and will allow us to delineate novel mechanisms. Through innovative time course studies and measurements in serial human muscle biopsies, we will place the etiology of muscle atrophy firmly in the context of mitochondrial biology and will contribute to a better precision medicine approach to prevent and treat disuse atrophy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	ADVENTIST HEALTH SYSTEM/SUNBELT INC	601 E ROLLINS ST	ORLANDO	FL	32803	ORANGE	USA	Aging Research	000	5	6/20/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $691,336 )
2022	2022	ADVENTIST HEALTH SYSTEM/SUNBELT, INC.	601 E ROLLINS ST	ORLANDO	FL	32803	ORANGE	USA	Aging Research	000	5	7/8/2022	NON-COMPETING CONTINUATION	$691,336
														Subtotal = $691,336

Issue Date FY: 2021 ( Subtotal = $703,318 )
2021	2021	ADVENTIST HEALTH SYSTEM/SUNBELT, INC.	601 E ROLLINS ST	ORLANDO	FL	32803	ORANGE	USA	Aging Research	000	4	5/26/2021	NON-COMPETING CONTINUATION	$703,318
														Subtotal = $703,318

Issue Date FY: 2020 ( Subtotal = $710,926 )
2020	2020	ADVENTIST HEALTH SYSTEM/SUNBELT, INC.	601 E ROLLINS ST	ORLANDO	FL	32803	ORANGE	USA	Aging Research	000	3	8/6/2020	NON-COMPETING CONTINUATION	$710,926
														Subtotal = $710,926

Issue Date FY: 2019 ( Subtotal = $725,580 )
2019	2019	ADVENTIST HEALTH SYSTEM/SUNBELT, INC.	601 E ROLLINS ST	ORLANDO	FL	32803	ORANGE	USA	Aging Research	001	2	5/31/2019	NON-COMPETING CONTINUATION	$725,580
2019	2018	ADVENTIST HEALTH SYSTEM/SUNBELT, INC.	601 E ROLLINS ST	ORLANDO	FL	32803	ORANGE	USA	Aging Research	000	1	2/25/2019	NEW	$0
														Subtotal = $725,580

Issue Date FY: 2018 ( Subtotal = $728,306 )
2018	2018	ADVENTIST HEALTH SYSTEM/SUNBELT, INC.	601 E ROLLINS ST	ORLANDO	FL	32803	ORANGE	USA	Aging Research	000	1	8/16/2018	NEW	$694,433
2018	2018	ADVENTIST HEALTH SYSTEM/SUNBELT, INC.	601 E ROLLINS ST	ORLANDO	FL	32803	ORANGE	USA	Aging Research	001	1	8/30/2018	NEW	$33,873
														Subtotal = $728,306

Grand Total All Awards = $3,559,466

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The role of type 2 diabetes on skeletal muscle atrophy and recovery following bed rest in older adults

Award Number: R01AG060153

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2018

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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