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Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)

Award Number: R01AG058969
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY / ABSTRACT This competitive renewal of “MESA-MIND” (R01AG058969) is a cooperative and multi-disciplinary project ideally positioned to fill critical gaps in our understanding of both the vascular contributions to cognitive impairment and dementia (VCID) in context of Alzheimer’s disease (AD) and related disorders (ADRD) and the noted the health disparities in VCID and AD/ADRD. This project is an extension of the Multi-Ethnic Study of Atherosclerosis (MESA), a large multi-ethnic cohort of 6814 adults now 65 and older (self-reported: 38% White, 28% Black, 22% Hispanic, and 12% Chinese Americans) with deep subclinical vascular phenotyping and stored plasma over the past two decades. Through initiation of MESA-MIND’s cognitive and imaging visits, we have demonstrated excellent feasibility to recruit MESA participants into a multimodal and multilingual ADRD research study more than 15 years after MESA baseline. The primary focus of MESA-MIND remains to define the subclinical vascular contributions to changes in AD/ADRD biomarkers and cognitive phenotypes of impairment. In MESA-MIND, we have shown that subclinical biomarkers of arteriosclerosis and atherosclerosis were associated with imaging biomarkers (MRI and PET), cognitive decline, and cognitive impairment. These peripheral vascular and imaging biomarkers of vascular disease tend to be higher in men, as well as self-reported Black and Hispanic older adults; differences that were partially explained by social determinants of health. MESA has recently built the infrastructure to define the temporal sequence of molecular dysregulation with longitudinal plasma AD biomarkers and ‘omics data over two decades. This renewal cycle seeks to make major strides in our mechanistic understanding of structural, functional, and molecular drivers of “subclinical VCID” by: (1) leveraging MESA’s longitudinal and extensive subclinical vascular biomarkers paired with recent advancements in high-throughput plasma AD biomarkers, proteomics and metabolomics technologies applied to MESA and (2) expanding these data resources through two new exams (“MIND C” and “MIND D”) over the next 5 years. These new resources will enable examination of the molecular (genomic, proteomic, and metabolomic) aspects shared by vascular disorders, AD biomarkers, and cognitive phenotypes as well as the temporal sequence of transition from subclinical disease to clinical phenotype. Each research question in MESA-MIND is designed to consider the consistency of subgroup analyses by gender, racial, and ethnic groups to characterize the health disparities in VCID/AD/ADRD in the context of social determinants of health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	001	6	12/5/2024	COMPETING CONTINUATION	$821,611
2025	2022	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	000	5	12/5/2024	NON-COMPETING CONTINUATION	-$821,611
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $4,759,428 )
2024	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	000	6	6/18/2024	COMPETING CONTINUATION	$4,759,428
														Subtotal = $4,759,428

Issue Date FY: 2022 ( Subtotal = $3,776,527 )
2022	2022	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	000	5	6/15/2022	NON-COMPETING CONTINUATION	$3,776,527
														Subtotal = $3,776,527

Issue Date FY: 2021 ( Subtotal = $3,899,242 )
2021	2021	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	000	4	6/8/2021	NON-COMPETING CONTINUATION	$3,899,242
														Subtotal = $3,899,242

Issue Date FY: 2020 ( Subtotal = $3,609,964 )
2020	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	000	3	5/28/2020	NON-COMPETING CONTINUATION	$3,609,964
														Subtotal = $3,609,964

Issue Date FY: 2019 ( Subtotal = $3,686,938 )
2019	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	001	1	12/17/2018	SUPPLEMENT FOR EXPANSION	$113,789
2019	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	002	2	6/19/2019	NON-COMPETING CONTINUATION	$3,573,149
2019	2018	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	000	1	12/13/2018	NEW	$0
														Subtotal = $3,686,938

Issue Date FY: 2018 ( Subtotal = $3,663,134 )
2018	2018	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	000	1	8/8/2018	NEW	$3,663,134
														Subtotal = $3,663,134

Grand Total All Awards = $23,395,233

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Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)

Award Number: R01AG058969

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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