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Alzheimer's dementia onset and progression in international cohorts (Amended)

Award Number: R01AG058676
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2018
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Alzheimer's dementia onset and progression in international cohorts (Amended) - PROJECT SUMMARY / ABSTRACT This R01 application, entitled ‘Alzheimer’s dementia onset and progression in international cohorts (Amended)’ is a resubmission in response to PAR-17-054. By the year 2050 it is projected that there will be 13.5 million Americans with Alzheimer’s disease (AD) at a cost of $1.1 trillion. The increasing incidence of AD and related dementias presents a massive global health challenge requiring a committed response from researchers, clinicians and funding bodies. The rise in dementia diagnoses presents multiple challenges for researchers and clinicians alike. Paramount amongst these are early, accurate identification of dementia and its aetiology, in parallel with ensuring that clinical research findings are translated into tangible outcomes in the prevention, diagnosis, treatment, and care for people at risk of or manifesting dementia. To facilitate this, a better understanding of the risk and protective factors which precipitate or delay a dementia diagnosis is essential. Our proposal will leverage the power of five leading well characterized Alzheimer’s cohorts to clarify risk and protective factors for Alzheimer’s disease and related dementias: the Adult Children Study (ACS), the Alzheimer’s Disease Neuroimaging Initiative (ADNI), the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL), the Dominantly Inherited Alzheimer Network (DIAN) and the National Alzheimer's Coordinating Center (NACC). This international consortium will provide us with access to data spanning the entire disease lifespan; from its preclinical stages through to post mortem analyses. Data from participants presenting at three or more timepoints will be used to ensure robust findings. This application will establish and validate the impact of demographics, genotype and comorbidities on the onset and progression rates of Alzheimer’s dementia. This work will enable us to establish and validate hazard scores for disease onset and severity using clinical markers across the domains of cognition, neuroimaging, and biomarkers. The datasets of these cohorts will be harmonized to enable an improved understanding of the risk and protective factors for Alzheimer’s dementia. This application will lead to the generation of risk hazard scores based on clinically available technologies. These findings will be directly transferable to the clinical setting and will also enable more accurate identification of suitable candidates for clinical trials targeting Alzheimer’s disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	UNIVERSITY OF MELBOURNE	RAYMOND PRIESTLEY BLDG UNIV OF MELB	MELBOURNE	VICTORIA			AUS	Aging Research	000	5	5/30/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $2,083,798 )
2022	2022	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Aging Research	002	5	7/28/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Aging Research	001	5	7/26/2022	NON-COMPETING CONTINUATION	$2,083,798
2022	2021	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Trans-NIH Research Support	000	4	11/8/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,083,798

Issue Date FY: 2021 ( Subtotal = $2,319,244 )
2021	2021	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Aging Research	000	4	5/26/2021	NON-COMPETING CONTINUATION	$2,107,346
2021	2021	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC			AUS	Trans-NIH Research Support	001	4	8/25/2021	SUPPLEMENT FOR EXPANSION	$211,898
														Subtotal = $2,319,244

Issue Date FY: 2020 ( Subtotal = $2,128,853 )
2020	2020	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC	3010		AUS	Aging Research	001	3	7/20/2020	NON-COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC	3010		AUS	Aging Research	000	3	5/28/2020	NON-COMPETING CONTINUATION	$2,128,853
														Subtotal = $2,128,853

Issue Date FY: 2019 ( Subtotal = $2,150,430 )
2019	2019	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC	3010		AUS	Aging Research	001	2	6/17/2019	NON-COMPETING CONTINUATION	$2,150,430
2019	2018	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC	3052		AUS	Aging Research	000	1	11/7/2018	NEW	$0
														Subtotal = $2,150,430

Issue Date FY: 2018 ( Subtotal = $2,181,321 )
2018	2018	UNIVERSITY OF MELBOURNE	GRATTAN ST	PARKVILLE	VIC	3052		AUS	Aging Research	000	1	9/20/2018	NEW	$2,181,321
														Subtotal = $2,181,321

Grand Total All Awards = $10,863,646

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Alzheimer's dementia onset and progression in international cohorts (Amended)

Award Number: R01AG058676

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2018

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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