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Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat2)

Award Number: R01AG057234
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2019
PERIOD OF PERFORMANCE END DATE: 11/30/2030

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Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat2) - PROJECT SUMMARY The multi-partner consortium to expand dementia research in Latin America 2 (ReDLat2) seeks to address critical gaps in Latinos with Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). Latinos have been underrepresented in research despite being the most significant and fastest-growing minority in the United States (US). The project's long-term goal is to develop tailored models to assess and address the multimodal diversity across socioeconomic, genetic, and brain levels in Latino populations from Argentina, Brazil, Chile, Colombia, Mexico, and Peru compared to US participants. This multimodal approach will integrate data from 3,000 new participants (750 with AD, 750 with FTLD, 1,500 controls) with preexisting data (ReDLat1, N=3,000) via UCSF's strategic partners, and with secondary data from three other ReDLat-related R01s. Specific Aim 1 investigates how socioeconomic disparities affect dementia phenotypes across different data modalities, such as clinical, cognitive, and neuroimaging data. Aim 1 will include Latin America and the US participants, hypothesizing that adverse socioeconomic conditions (measured with social determinants of health, socioeconomic status, and inequality metrics) influence the multimodal phenotypes in aging and dementia. Aim 2 seeks to identify rare and common genetic variants contributing to AD and FTLD within large families and case-control cohorts across Latin America. Whole genome sequencing with short and long reads will be used to discover novel genes and test a newly developed Latino-specific polygenic risk score (PRS). Aim 3 will develop models to evaluate participants' brain age gap (BAG), utilizing computational semiempirical modeling and generative approaches that consider socioeconomic factors and genetic risks. The hypothesis is that these models will show differences in accelerated aging among Latinos compared to non-Latinos, modulated by socioeconomic and genetic risks. The methodology involves a comprehensive and harmonized data collection strategy encompassing clinical assessments, plasma biomarkers, cognitive testing, genomic analysis, and neuroimaging. These participants will be drawn from Latin America and the US, focusing on those socioeconomically disadvantaged and with familial antecedents of dementia. Whole genome sequencing will identify genetic markers and variants associated with dementia, complemented with plasma biomarkers (Aβ40, Aβ42, p-tau proteins, and others). The study will create a unique dataset that includes genetic data and measures of socioeconomic disparities from underrepresented groups, which will be invaluable for numerous scientific inquiries. This project is poised to transform the understanding of dementia in Latinos by integrating genetic and environmental factors, thus facilitating the development of targeted interventions and treatments that are culturally and genetically appropriate. The success of this initiative could lead to broader applications in other minority populations, ultimately contributing to more personalized and effective healthcare solutions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $3,423,861 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	002	6	3/12/2026	COMPETING CONTINUATION	$0
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	005	6	3/24/2026	SUPPLEMENT FOR EXPANSION	$139,112
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	008	6	3/27/2026	SUPPLEMENT FOR EXPANSION	$241,510
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	003	6	3/20/2026	SUPPLEMENT FOR EXPANSION	$809,061
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	009	6	3/30/2026	SUPPLEMENT FOR EXPANSION	$175,388
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	010	6	3/31/2026	SUPPLEMENT FOR EXPANSION	$200,466
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	004	6	3/23/2026	SUPPLEMENT FOR EXPANSION	$144,843
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	001	6	3/5/2026	COMPETING CONTINUATION	$1,307,141
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	007	6	3/26/2026	SUPPLEMENT FOR EXPANSION	$201,222
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	006	6	3/25/2026	SUPPLEMENT FOR EXPANSION	$205,118
2026	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	5	2/27/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,423,861

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	5	3/18/2025	NON-COMPETING CONTINUATION	$0
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	001	5	4/14/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $480,355 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	5	4/19/2024	NON-COMPETING CONTINUATION	$480,355
														Subtotal = $480,355

Issue Date FY: 2023 ( Subtotal = $512,850 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	4	3/20/2023	NON-COMPETING CONTINUATION	$512,850
														Subtotal = $512,850

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	3	5/2/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $521,480 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	3	4/12/2021	NON-COMPETING CONTINUATION	$521,480
														Subtotal = $521,480

Issue Date FY: 2020 ( Subtotal = $807,005 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	006	2	8/20/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	005	2	8/18/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	008	2	9/12/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$204,167
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	004	2	8/14/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$807,005
2020	2019	FUNDACION INECO PARA LA INVESTIGACION EN NEUROCIENCIAS COGNITIVAS	PACHECO DE MELO JOSE 1854	CIUDAD DE BUENOS AIRES		C1126AAB		ARG	Aging Research	001	1	4/6/2020	NEW	$0
2020	2019	FUNDACION INECO PARA LA INVESTIGACION EN NEUROCIENCIAS COGNITIVAS	PACHECO DE MELO JOSE 1854	CIUDAD DE BUENOS AIRES		C1126AAB		ARG	Aging Research	003	1	8/12/2020	NEW	$0
2020	2019	CENTRO DE PSICOLOGIA MEDICA SAN MARTIN DE TOURS S.R.L.	PACHECO DE MELO 1860	CIUDAD DE BUENOS AIRES		C1126AAB		ARG	Aging Research	000	1	1/8/2020	NEW	$0
2020	2019	FUNDACION INECO PARA LA INVESTIGACION EN NEUROCIENCIAS COGNITIVAS	PACHECO DE MELO JOSE 1854	CIUDAD DE BUENOS AIRES		C1126AAB		ARG	Aging Research	007	1	9/12/2020	NEW	-$204,167
2020	2019	FUNDACION INECO PARA LA INVESTIGACION EN NEUROCIENCIAS COGNITIVAS	PACHECO DE MELO JOSE 1854	CIUDAD DE BUENOS AIRES		C1126AAB		ARG	Aging Research	002	1	4/8/2020	NEW	$0
														Subtotal = $807,005

Issue Date FY: 2019 ( Subtotal = $334,244 )
2019	2019	CENTRO DE PSICOLOGIA MEDICA SAN MARTIN DE TOURS S.R.L.	PACHECO DE MELO 1860	CIUDAD DE BUENOS AIRES		C1126AAB		ARG	Aging Research	000	1	9/27/2019	NEW	$334,244
														Subtotal = $334,244

Grand Total All Awards = $6,079,795

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Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat2)

Award Number: R01AG057234

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2019

PERIOD OF PERFORMANCE END DATE: 11/30/2030

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