Monday, June 30, 2025 6/30/2025

Formation and Propagation of Tau Oligomeric Strains in Alzheimer's Disease

Award Number: R01AG054025
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2016
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Formation and Propagation of Tau Oligomeric Strains in Alzheimer's Disease - The pathological aggregation of the microtubule-associated protein tau and its subsequent deposition in neurofibrillary tangles (NFTs) are defining histopathological features of Alzheimer’s disease (AD) and many other neurodegenerative disorders. Although accumulated tau protein aggregates in the brain are a consistent hallmark of AD, there is a vast array in the progression rate of disease and diversity in symptoms. An expansive body of evidence demonstrates that AD shares important characteristics with prion diseases in terms of protein aggregation where conformational variants of tau and Aβ can induce templating of aggregation in cell models or in vivo. Recent advances have spurred a series of critical questions as i) how variable tau aggregate strains can be, ii) formation of tau strains with the ability of spreading within the brain regions and induce aggregation of native tau, iii) the propensity of diverse tau strains to precede and accompany other amyloid aggregation. Our central hypothesis is that the biological properties of AD-relevant tau oligomer strains in specific genetic background and mixed protein pathologies are encoded in the structure of these aggregates. Thus, the interplay/competition between distinct tau oligomer strains is a critical determinant in controlling the extent of disease progression and initiating definite toxicity cascades in AD. The identification of the most dominant and latent strains will be crucial for the design of personalized therapeutic strategies by enhancing accurate targeting of the toxic species. This proposal is based on our excellent progress and exciting preliminary data and supported by our competent team and collaborators, will address tau oligomeric strain biology and the unexplored role of domination in oligomer stains, thus regulating disease progression and phenotypes in AD, one of the most relevant contemporary NIH mission areas. The novel insights gained from this study will lead to the future designing of clinical trials and the possibility for personalized medicine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $751,899 )
2025	2025	UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON	301 UNIVERSITY BLVD	GALVESTON	TX	77555	GALVESTON	USA	Aging Research	001	9	6/18/2025	NON-COMPETING CONTINUATION	$61,379
2025	2025	UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON	301 UNIVERSITY BLVD	GALVESTON	TX	77555	GALVESTON	USA	Aging Research	000	9	3/14/2025	NON-COMPETING CONTINUATION	$690,520
														Subtotal = $751,899

Issue Date FY: 2024 ( Subtotal = $776,725 )
2024	2024	UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON	301 UNIVERSITY BLVD	GALVESTON	TX	77555	GALVESTON	USA	Aging Research	000	8	4/18/2024	NON-COMPETING CONTINUATION	$776,725
														Subtotal = $776,725

Issue Date FY: 2023 ( Subtotal = $785,997 )
2023	2023	UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON	301 UNIVERSITY BLVD	GALVESTON	TX	77555	GALVESTON	USA	Aging Research	000	7	3/24/2023	NON-COMPETING CONTINUATION	$785,997
														Subtotal = $785,997

Issue Date FY: 2022 ( Subtotal = $805,576 )
2022	2022	UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON	301 UNIVERSITY BLVD	GALVESTON	TX	77555	GALVESTON	USA	Aging Research	000	6	5/16/2022	COMPETING CONTINUATION	$805,576
														Subtotal = $805,576

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON	301 UNIVERSITY BLVD	GALVESTON	TX	77555	GALVESTON	USA	Aging Research	000	5	7/30/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $387,500 )
2020	2020	UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON	301 UNIVERSITY BLVD	GALVESTON	TX	77555	GALVESTON	USA	Aging Research	000	5	3/12/2020	NON-COMPETING CONTINUATION	$387,500
														Subtotal = $387,500

Issue Date FY: 2019 ( Subtotal = $387,500 )
2019	2019	UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON	301 UNIVERSITY BLVD	GALVESTON	TX	77555	GALVESTON	USA	Aging Research	000	4	3/29/2019	NON-COMPETING CONTINUATION	$387,500
														Subtotal = $387,500

Issue Date FY: 2018 ( Subtotal = $387,500 )
2018	2018	UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON	301 UNIVERSITY BLVD	GALVESTON	TX	77555	GALVESTON	USA	Aging Research	000	3	4/26/2018	NON-COMPETING CONTINUATION	$387,500
														Subtotal = $387,500

Issue Date FY: 2017 ( Subtotal = $387,500 )
2017	2017	UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON	301 UNIVERSITY BLVD	GALVESTON	TX	77555	GALVESTON	USA	Aging Research	001	2	6/22/2017	NON-COMPETING CONTINUATION	$38,750
2017	2017	UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON	301 UNIVERSITY BLVD	GALVESTON	TX	77555	GALVESTON	USA	Aging Research	000	2	4/13/2017	NON-COMPETING CONTINUATION	$348,750
														Subtotal = $387,500

Issue Date FY: 2016 ( Subtotal = $387,500 )
2016	2016	UNIVERSITY OF TEXAS, MEDICAL BRANCH AT GALVESTON	1000 STRAND	GALVESTON	TX	77550	GALVESTON	USA	Aging Research	000	1	7/7/2016	NEW	$387,500
														Subtotal = $387,500

Grand Total All Awards = $5,057,697

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Formation and Propagation of Tau Oligomeric Strains in Alzheimer's Disease

Award Number: R01AG054025

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2016

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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