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Healthy transitions from mid-life to early older age: biomedical follow-up of 1958 Birth Cohort Study members at age 60

Award Number: R01AG052519
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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7. Project Summary/Abstract The unrivalled increase in human life expectancy over the last century has been one of the greatest achievements of public health medicine. However, it also poses new and unique challenges in health and social care, in particular the increased burden of chronic diseases and associated ageing states, including cognitive impairment and frailty. Understanding the occurrence and determinants of these ageing outcomes has become a global research priority with considerable policy implications. Several studies have been established in middle- and older-aged populations in the US (HRS, MIDUS) with the capacity to offer much- needed insights into these issues. However, it has recently become evident that the processes that underlie ageing states begin much sooner in the life course than originally thought, in some cases as early as birth or preconception. It is in such life course-orientated studies that the USA is surprisingly bereft. The 1958 British Birth Cohort Study in the UK is the largest long-running study of this genre. With the study members approaching 60 years of age, when problems of ageing begin to emerge with frequency, we will carry out a detailed phenotypic and genotypic survey which covers an array of areas including biological, psychological, socioeconomic and behavioural characteristics. Uniquely, these new data will allow us to answer a series of important research questions of public health importance, ranging from identifying the policy-modifiable behaviours and biological mechanisms in mid-life that successfully reverse the effects of earlier life exposures and adversities on ageing outcomes, through to examining the long term influence of early life educational interventions on social, health, and ageing outcomes in older age, on to running a series of cross-country, and cross-cohort comparisons, to enable us to highlight where such processes are changing across generations, or between countries. These data will become publically available to bone fide population scientists soon after collection, so providing an unrivalled resource for the scientific community to investigate a range of policy- relevant issues.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Aging Research	000	5	7/8/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Aging Research	000	5	10/19/2022	NON-COMPETING CONTINUATION	$0
2023	2021	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Aging Research	001	5	6/22/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $323,254 )
2021	2021	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Aging Research	000	5	7/15/2021	NON-COMPETING CONTINUATION	$323,254
														Subtotal = $323,254

Issue Date FY: 2020 ( Subtotal = $517,421 )
2020	2020	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON		WC1E 6BT		GBR	Aging Research	000	3	3/4/2020	SUPPLEMENT FOR EXPANSION	$194,167
2020	2020	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON		WC1E 6BT		GBR	Aging Research	001	4	9/3/2020	NON-COMPETING CONTINUATION	$323,254
														Subtotal = $517,421

Issue Date FY: 2019 ( Subtotal = $323,254 )
2019	2019	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON		WC1E 6BT		GBR	Aging Research	000	3	7/1/2019	NON-COMPETING CONTINUATION	$323,254
														Subtotal = $323,254

Issue Date FY: 2018 ( Subtotal = $441,994 )
2018	2018	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON		WC1E 6BT		GBR	Aging Research	001	2	9/11/2018	SUPPLEMENT FOR EXPANSION	$117,924
2018	2018	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON		WC1E 6BT		GBR	Aging Research	000	2	8/3/2018	NON-COMPETING CONTINUATION	$324,070
														Subtotal = $441,994

Issue Date FY: 2017 ( Subtotal = $324,438 )
2017	2017	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON		WC1E 6BT		GBR	Aging Research	000	1	9/9/2017	NEW	$324,438
														Subtotal = $324,438

Grand Total All Awards = $1,930,361

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Healthy transitions from mid-life to early older age: biomedical follow-up of 1958 Birth Cohort Study members at age 60

Award Number: R01AG052519

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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