Thursday, November 21, 2024 11/21/2024

Circadian Clock and Dietary Restriction

Award Number: R01AG039547
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Abstract

Diet is an important factor influencing health and disease. Calorie restriction (CR) improves metabolism, delays aging, and reduces the incidence of many age-associated diseases such as cancer, diabetes, and cardiometabolic. mTOR signaling pathway plays a central role in the control of aging and CR mechanisms. We will expand the current model on the regulation of mTOR signaling by diet in vivo, by exploring crosstalk between diet and circadian rhythms in metabolic signaling and gene expression. We will test the hypothesis that CR reprograms the expression of mTOR regulatory network through circadian clock-dependent mechanisms. The reprogramming changes the balance in the mTOR network and impacts the response of mTOR signaling to growth factors and nutrients challenges. Reprogramming of circadian rhythms in mTOR signaling is important for metabolic adaptation to CR. In vivo and ex vivo approaches and wild-type and circadian clock mutant mice will be used to compare the impact of CR with the impact of AL and fasting on mTOR signaling. The study will help to dissect contributions of fasting and reduced calorie intake to CR improved metabolism and longevity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $546,594 )
2024	2024	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	001	13	6/26/2024	SUPPLEMENT FOR EXPANSION	$63,351
2024	2024	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	000	13	6/13/2024	NON-COMPETING CONTINUATION	$483,243
														Subtotal = $546,594

Issue Date FY: 2023 ( Subtotal = $541,315 )
2023	2023	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	003	12	6/22/2023	NON-COMPETING CONTINUATION	$483,243
2023	2023	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	004	12	6/27/2023	SUPPLEMENT FOR EXPANSION	$58,072
2023	2022	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	002	11	3/7/2023	COMPETING CONTINUATION	$0
2023	2022	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	001	11	1/18/2023	COMPETING CONTINUATION	$140,852
2023	2021	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	000	10	1/18/2023	NON-COMPETING CONTINUATION	-$140,852
														Subtotal = $541,315

Issue Date FY: 2022 ( Subtotal = $471,737 )
2022	2022	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	001	11	9/27/2022	COMPETING CONTINUATION	$471,737
2022	2021	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	000	10	9/27/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $471,737

Issue Date FY: 2021 ( Subtotal = $304,425 )
2021	2021	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	000	10	3/15/2021	NON-COMPETING CONTINUATION	$304,425
														Subtotal = $304,425

Issue Date FY: 2020 ( Subtotal = $304,425 )
2020	2020	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	000	9	2/18/2020	NON-COMPETING CONTINUATION	$304,425
														Subtotal = $304,425

Issue Date FY: 2019 ( Subtotal = $304,425 )
2019	2019	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	000	8	3/1/2019	NON-COMPETING CONTINUATION	$304,425
														Subtotal = $304,425

Issue Date FY: 2018 ( Subtotal = $304,425 )
2018	2018	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	000	7	5/14/2018	NON-COMPETING CONTINUATION	$304,425
														Subtotal = $304,425

Issue Date FY: 2017 ( Subtotal = $304,425 )
2017	2017	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	003	6	5/16/2017	COMPETING CONTINUATION	$47,201
2017	2017	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	001	6	3/7/2017	COMPETING CONTINUATION	$304,425
2017	2015	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	002	5	5/16/2017	NON-COMPETING CONTINUATION	-$47,201
2017	2015	CLEVELAND STATE UNIVERSITY	2121 EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	000	5	3/2/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $304,425

Issue Date FY: 2015 ( Subtotal = $282,367 )
2015	2015	CLEVELAND STATE UNIVERSITY	1983 E 24TH ST, & EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	000	5	5/15/2015	NON-COMPETING CONTINUATION	$282,367
														Subtotal = $282,367

Issue Date FY: 2014 ( Subtotal = $291,100 )
2014	2014	CLEVELAND STATE UNIVERSITY	1983 E 24TH ST, & EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	000	4	5/22/2014	NON-COMPETING CONTINUATION	$291,100
														Subtotal = $291,100

Issue Date FY: 2013 ( Subtotal = $275,090 )
2013	2013	CLEVELAND STATE UNIVERSITY	1983 E 24TH ST, & EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	000	3	8/15/2013	NON-COMPETING CONTINUATION	$275,090
														Subtotal = $275,090

Issue Date FY: 2012 ( Subtotal = $291,100 )
2012	2012	CLEVELAND STATE UNIVERSITY	1983 E 24TH ST, & EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	000	2	8/6/2012	NON-COMPETING CONTINUATION	$291,100
														Subtotal = $291,100

Issue Date FY: 2011 ( Subtotal = $291,100 )
2011	2011	CLEVELAND STATE UNIVERSITY	1983 E 24TH ST, & EUCLID AVE	CLEVELAND	OH	44115	CUYAHOGA	USA	Aging Research	000	1	9/12/2011	NEW	$291,100
														Subtotal = $291,100

Grand Total All Awards = $4,512,528

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Circadian Clock and Dietary Restriction

Award Number: R01AG039547

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer