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DNA METHYLATION IN ALZHEIMERS DISEASE AND NORMALLY AGED BRAIN

Award Number: R01AG036400
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2009
PERIOD OF PERFORMANCE END DATE: 08/31/2014

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DNA METHYLATION IN ALZHEIMERS DISEASE AND NORMALLY AGED BRAIN - DESCRIPTION (provided by applicant): The proposed research represents the coordination of a number of existing facilities and resources aimed at defining the role(s) of DNA methylation in the molecular pathology of Alzheimer's disease. We will integrate the expertise of the Coleman/Rogers lab in Alzheimer's disease with the expertise of the Laird lab in DNA methylation to identify DNA methylation sites in a genome wide study of an affected (temporal neocortex) and a minimally affected (cerebellum) brain region of Alzheimer's disease (AD) and non demented control cases. The 550 brains to be utilized in this proposed study will come from the comprehensive and outstanding Brain Bank at Sun Health Research Institute. Since promoter DNA methylation only relates to the potential for gene expression, it may not be a very good predictor of gene expression differences. Consequently, we will determine the relationship between specific sites of DNA methylation and altered expression of specific genes in AD by correlating our DNA methylation data with an existing set of Affymetrix data on gene expression in ~100 normal and AD brains. Finally, to specify cell classes affected we will conduct combined immunohistochemistry and in situ htbridization studies to define cell classes affected by specific DNA methylation/expression changes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $368,033 )
2013	2013	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	002	6	9/19/2013	NON-COMPETING CONTINUATION	$368,033
2013	2012	SUN HEALTH RESEARCH INSTITUTE	P.O. BOX 1278	SUN CITY	AZ	85372	MARICOPA	USA	Aging Research	000	4	9/17/2013	NON-COMPETING CONTINUATION	-$148,113
2013	2012	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	001	5	9/18/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$148,113
														Subtotal = $368,033

Issue Date FY: 2012 ( Subtotal = $388,463 )
2012	2012	SUN HEALTH RESEARCH INSTITUTE	P.O. BOX 1278	SUN CITY	AZ	85372	MARICOPA	USA	Aging Research	000	4	8/8/2012	NON-COMPETING CONTINUATION	$388,463
														Subtotal = $388,463

Issue Date FY: 2011 ( Subtotal = $388,536 )
2011	2011	SUN HEALTH RESEARCH INSTITUTE	P.O. BOX 1278	SUN CITY	AZ	85372	MARICOPA	USA	Aging Research	000	3	8/5/2011	NON-COMPETING CONTINUATION	$388,536
														Subtotal = $388,536

Issue Date FY: 2010 ( Subtotal = $494,036 )
2010	2010	SUN HEALTH RESEARCH INSTITUTE	P.O. BOX 1278	SUN CITY	AZ	85372	MARICOPA	USA	Aging Research	001	2	9/13/2010	SUPPLEMENT FOR EXPANSION	$100,000
2010	2010	SUN HEALTH RESEARCH INSTITUTE	P.O. BOX 1278	SUN CITY	AZ	85372	MARICOPA	USA	Aging Research	000	2	8/23/2010	NON-COMPETING CONTINUATION	$394,036
														Subtotal = $494,036

Issue Date FY: 2009 ( Subtotal = $404,753 )
2009	2009	SUN HEALTH RESEARCH INSTITUTE	P.O. BOX 1278	SUN CITY	AZ	85372	MARICOPA	USA	Aging Research	000	1	9/2/2009	NEW	$404,753
														Subtotal = $404,753

Grand Total All Awards = $2,043,821

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DNA METHYLATION IN ALZHEIMERS DISEASE AND NORMALLY AGED BRAIN

Award Number: R01AG036400

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2009

PERIOD OF PERFORMANCE END DATE: 08/31/2014

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