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Characterizing the Behavior Profile of Healthy Cognitive Aging

Award Number: R01AG034374
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2009
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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Characterizing the Behavior Profile of Healthy Cognitive Aging - ABSTRACT Prevention of late life cognitive decline ranks among the most important public health challenges, and identification of the profile of healthy cognitive aging is an essential step. The proposed study will continue a highly successful program of research that has transformed the field’s understanding of healthy cognitive aging (R01AG34374). We conceptualize healthy cognitive aging as the late life cognitive change that is not due to known pathologic processes (e.g., AD/ADRD pathologies), and our research capitalizes on the detailed longitudinal cognitive and pathologic data from the Religious Orders Study and Rush Memory and Aging Project (ROSMAP). The central idea is that we can precisely characterize pathologic cognitive aging by linking pathologic indices to longitudinal cognitive trajectories and then identify healthy cognitive aging (i.e., residual change). In prior cycles, we reported that: a) common AD/ADRD neuropathologies account for much of the decline previously attributed to healthy cognitive aging but less than half of the variation in decline overall; b) nonlinear, terminal change represents a separate pathologic process and a major driver of decline; c) AD/ADRD neuropathologies differentially impact trajectories of specific cognitive systems; and d) our newly developed “cognitive age” metric is a robust prognostic indicator of adverse cognitive outcomes. The overall goal of the proposed continuation is to further elucidate the profile of healthy cognitive aging and translate our work in decedents into the living to prospectively distinguish healthy from pathologic cognitive aging. The proposed study will incorporate new neuropathologic indices, neuroimaging, and promising blood biomarkers of AD and neurodegeneration and apply a highly innovative statistical approach to precisely identify the profile of healthy cognitive aging. Building on prior work, we will first identify healthy cognitive aging among autopsied persons with detailed pathologic data. Importantly, we will then extend this approach to living persons. Finally, we will integrate new biomarker and ante-mortem neuroimaging data with our cognitive age metric to develop criteria for prediction of incident MCI and Alzheimer’s dementia and validate them in an independent dataset from a biracial, population-based sample, the Chicago Health and Aging Project (CHAP). Thus, the proposed study offers an innovative approach to address a fundamental and longstanding challenge in cognitive aging research. This work also will facilitate early and accurate identification of individuals at high risk of developing cognitive impairment, an urgent priority in aging research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $878,179 )
2025	2025	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	001	14	6/20/2025	NON-COMPETING CONTINUATION	$71,687
2025	2025	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	000	14	4/28/2025	NON-COMPETING CONTINUATION	$806,492
														Subtotal = $878,179

Issue Date FY: 2024 ( Subtotal = $940,498 )
2024	2024	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	000	13	7/5/2024	NON-COMPETING CONTINUATION	$940,498
														Subtotal = $940,498

Issue Date FY: 2023 ( Subtotal = $940,498 )
2023	2023	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	000	12	6/12/2023	NON-COMPETING CONTINUATION	$940,498
														Subtotal = $940,498

Issue Date FY: 2022 ( Subtotal = $940,498 )
2022	2022	RUSH UNIVERSITY MEDICAL CENTER	1620 W HARRISON ST	CHICAGO	IL	60612	COOK	USA	Aging Research	000	11	5/5/2022	COMPETING CONTINUATION	$940,498
2022	2019	RUSH UNIVERSITY MEDICAL CENTER	1620 W HARRISON ST	CHICAGO	IL	60612	COOK	USA	Aging Research	001	10	8/26/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $940,498

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	000	10	4/2/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $583,721 )
2019	2019	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	000	10	5/28/2019	NON-COMPETING CONTINUATION	$583,721
														Subtotal = $583,721

Issue Date FY: 2018 ( Subtotal = $596,156 )
2018	2018	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	000	9	4/24/2018	NON-COMPETING CONTINUATION	$596,156
2018	2018	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	001	9	6/22/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $596,156

Issue Date FY: 2017 ( Subtotal = $604,525 )
2017	2017	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	000	8	3/22/2017	NON-COMPETING CONTINUATION	$544,073
2017	2017	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	001	8	6/14/2017	NON-COMPETING CONTINUATION	$60,452
														Subtotal = $604,525

Issue Date FY: 2016 ( Subtotal = $619,335 )
2016	2016	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	7	3/28/2016	NON-COMPETING CONTINUATION	$619,335
														Subtotal = $619,335

Issue Date FY: 2015 ( Subtotal = $627,967 )
2015	2015	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	001	6	7/3/2015	COMPETING CONTINUATION	$627,967
2015	2013	RUSH UNIVERSITY MEDICAL CENTER	1653 WEST CONGRESS WAY	CHICAGO	IL	60612	COOK	USA	Aging Research	000	5	7/1/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $627,967

Issue Date FY: 2013 ( Subtotal = $248,868 )
2013	2013	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	5	7/23/2013	NON-COMPETING CONTINUATION	$248,868
														Subtotal = $248,868

Issue Date FY: 2012 ( Subtotal = $263,352 )
2012	2012	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	4	7/20/2012	NON-COMPETING CONTINUATION	$263,352
														Subtotal = $263,352

Issue Date FY: 2011 ( Subtotal = $263,352 )
2011	2011	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	3	7/29/2011	NON-COMPETING CONTINUATION	$263,352
														Subtotal = $263,352

Issue Date FY: 2010 ( Subtotal = $243,540 )
2010	2010	RUSH-PRESBYTERIAN-ST LUKE'S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	2	7/15/2010	NON-COMPETING CONTINUATION	$243,540
														Subtotal = $243,540

Issue Date FY: 2009 ( Subtotal = $246,000 )
2009	2009	RUSH-PRESBYTERIAN-ST LUKE'S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	1	8/6/2009	NEW	$246,000
														Subtotal = $246,000

Grand Total All Awards = $7,996,489

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Characterizing the Behavior Profile of Healthy Cognitive Aging

Award Number: R01AG034374

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2009

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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