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Epidemiologic Study of Decision Making in Preclinical Alzheimer's Disease

Award Number: R01AG033678
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2009
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Epidemiologic Study of Decision Making in Preclinical Alzheimer's Disease - ABSTRACT Older adults face some of life’s most complex and influential decisions, just as cognitive, social, and other resources decline. Poor decision making, particularly in financial and health matters, poses enormous public health and economic challenges. Financial fraud offers an alarming example; older adults are among the most vulnerable and lose >$35 billion to fraud annually. The reasons why remain unclear, however, as decision making is a relatively nascent focus of aging research. In 2010, we began a study of decision making in the Rush Memory and Aging Project, an ongoing longitudinal clinical-pathologic study of aging. In the first two cycles, we enrolled >1,300 older adults, all of whom undergo detailed annual assessments of financial and health decision making. We reported that decision making involves a complex interplay among diverse resources and that many older adults—including those who are cognitively intact—exhibit poor decision making and are highly susceptible to scams. We also reported that poor decision making is associated with an increased risk of adverse outcomes including dementia and mild cognitive impairment (MCI). Further, in compelling preliminary studies, we found that neuroimaging and neuropathologic markers of brain aging and Alzheimer’s disease and related disorders (AD/ADRDs) degrade decision making. Thus, poor decision making is a harbinger of adverse health outcomes and may be due in part to age-related alterations in neural integrity. The overall goal of the proposed continuation (R01AG033678) is to identify the risk factors, consequences, and neurobiologic bases of age-related change in decision making. Continued annual data collection is necessary to precisely quantify age-related change in financial and health decision making. We will identify risk factors for decline independent of cognition and examine important health and financial impacts including financial exploitation and strain, outcomes we will newly measure. We also will newly incorporate in vivo neuroimaging to expand our focus on the neural basis of age-related change in decision making and complement clinical-pathologic findings. This study offers an unprecedented opportunity to link longitudinal decision making, behavioral, and adverse outcome data with neuroimaging and neuropathologic markers of neural integrity and AD/ADRDs. This integrative approach will efficiently determine the risk factors, consequences, and neurobiologic bases of age-related change in decision making and identify modifiable targets to improve decision making, health, and financial outcomes in old age.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $707,154 )
2025	2025	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	001	14	6/17/2025	NON-COMPETING CONTINUATION	$57,727
2025	2025	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	000	14	3/11/2025	NON-COMPETING CONTINUATION	$649,427
														Subtotal = $707,154

Issue Date FY: 2024 ( Subtotal = $729,449 )
2024	2024	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	001	13	6/10/2024	NON-COMPETING CONTINUATION	$72,945
2024	2024	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	000	13	1/4/2024	NON-COMPETING CONTINUATION	$656,504
														Subtotal = $729,449

Issue Date FY: 2023 ( Subtotal = $749,758 )
2023	2023	RUSH UNIVERSITY MEDICAL CENTER	1620 W HARRISON ST	CHICAGO	IL	60612	COOK	USA	Aging Research	000	12	1/18/2023	NON-COMPETING CONTINUATION	$749,758
														Subtotal = $749,758

Issue Date FY: 2022 ( Subtotal = $757,443 )
2022	2022	RUSH UNIVERSITY MEDICAL CENTER	1620 W HARRISON ST	CHICAGO	IL	60612	COOK	USA	Aging Research	003	11	8/16/2022	COMPETING CONTINUATION	$49,891
2022	2022	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	001	11	3/10/2022	COMPETING CONTINUATION	$757,443
2022	2019	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	000	10	3/2/2022	NON-COMPETING CONTINUATION	$0
2022	2019	RUSH UNIVERSITY MEDICAL CENTER	1620 W HARRISON ST	CHICAGO	IL	60612	COOK	USA	Aging Research	002	10	8/16/2022	NON-COMPETING CONTINUATION	-$49,891
														Subtotal = $757,443

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	000	10	5/3/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $583,392 )
2019	2019	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	000	10	4/26/2019	NON-COMPETING CONTINUATION	$583,392
														Subtotal = $583,392

Issue Date FY: 2018 ( Subtotal = $593,553 )
2018	2018	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	001	9	6/22/2018	NON-COMPETING CONTINUATION	$0
2018	2018	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	000	9	4/30/2018	NON-COMPETING CONTINUATION	$593,553
														Subtotal = $593,553

Issue Date FY: 2017 ( Subtotal = $613,445 )
2017	2017	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Aging Research	000	8	6/23/2017	NON-COMPETING CONTINUATION	$613,445
														Subtotal = $613,445

Issue Date FY: 2016 ( Subtotal = $571,959 )
2016	2016	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	7	4/22/2016	NON-COMPETING CONTINUATION	$571,959
														Subtotal = $571,959

Issue Date FY: 2015 ( Subtotal = $514,793 )
2015	2015	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	6	7/29/2015	COMPETING CONTINUATION	$514,793
														Subtotal = $514,793

Issue Date FY: 2014 ( Subtotal = $358,273 )
2014	2014	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	5	9/4/2014	SUPPLEMENT FOR EXPANSION	$358,273
														Subtotal = $358,273

Issue Date FY: 2013 ( Subtotal = $346,716 )
2013	2013	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	5	6/13/2013	NON-COMPETING CONTINUATION	$346,716
														Subtotal = $346,716

Issue Date FY: 2012 ( Subtotal = $369,555 )
2012	2012	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	4	6/20/2012	NON-COMPETING CONTINUATION	$369,555
														Subtotal = $369,555

Issue Date FY: 2011 ( Subtotal = $315,001 )
2011	2011	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	3	6/30/2011	NON-COMPETING CONTINUATION	$315,001
														Subtotal = $315,001

Issue Date FY: 2010 ( Subtotal = $322,278 )
2010	2010	RUSH-PRESBYTERIAN-ST LUKE'S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	2	6/16/2010	NON-COMPETING CONTINUATION	$322,278
														Subtotal = $322,278

Issue Date FY: 2009 ( Subtotal = $305,135 )
2009	2009	RUSH-PRESBYTERIAN-ST LUKE'S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	1	9/7/2009	NEW	$305,135
														Subtotal = $305,135

Grand Total All Awards = $7,837,904

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Epidemiologic Study of Decision Making in Preclinical Alzheimer's Disease

Award Number: R01AG033678

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2009

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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