Monday, July 7, 2025 7/7/2025

Brain Imaging, APOE & the Preclinical Course of Alzheimer's Disease

Award Number: R01AG031581
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2008
PERIOD OF PERFORMANCE END DATE: 03/31/2021

Group Awards By:

View Award Description

Brain Imaging, APOE & the Preclinical Course of Alzheimer's Disease - DESCRIPTION (provided by applicant): We request five years of continued support for the longitudinal study of cognitively normal persons with two, one, or no copies of the apolipoprotein E (APOE) ϵ4 allele, the major late-onset Alzheimer's disease (AD) susceptibility gene. This study utilizes an extensive battery of brain imaging, fluid biomarker, cognitive, and other measurements. Our program includes a cohort of 35 ϵ4 homozygotes, 50 ϵ4 heterozygotes, and 75 ϵ4 non-carriers to permit detection, tracking, and scientific study of preclinical AD in persons at three levels of risk and set the stage for the accelerated evaluation of preclinical AD treatments. It also includes a cohort of 15 ϵ4 carriers and 30 ϵ4 non-carriers from the Latino community to help establish the extent to which our findings are relevant to this understudied minority group. Persons in each genetic group were demographically matched and initially late middle-aged; their current age is 67 years (range 49-81). And, all participants have had genome-wide single nucleotide polymorphism (SNP) genotyping. During the proposed funding period participants will have PET measurements of regional cerebral metabolic rates of glucose (CMRgl) and fibrillar amyloid-β (Aβ) deposition, an expanded magnetic resonance imaging (MRI) battery, serum and plasma samples drawn and stored, and an extensive battery of clinical, neuropsychological, functional, and behavioral tests every two years. At least half will have longitudinal cerebrospinal fluid (CSF) samples drawn, stored, and assayed every two years. For nearly two decades our overriding goals have been to characterize the biomarker and cognitive measurements associated with preclinical AD and provide a foundation for the accelerated evaluation of promising prevention therapies. With the growing number of participants progressing to mild cognitive impairment (MCI) and dementia due to AD, we will begin to characterize the extent to which different biomarker and cognitive measurements predict subsequent rates of clinical progression. With an expanded arsenal of biomarkers and data analysis tools, we will further characterize the biological processes involved in the predisposition to AD. With our preclinical endophenotypes and complementary datasets, we will help clarify relationships between genetic risk factors and potentially dissociable elements of AD. With an expanded data and sample sharing program, we will provide an accessible worldwide resource to advance the study of preclinical AD. With this foundation of participants, samples, and longitudinal data, we will prepare for the evaluation of an Aβ-modifying agent in cognitively normal APOE ϵ4 carriers and help to advance a new era in AD prevention research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$197,044 )
2021	2018	BANNER HEALTH	901 E WILLETTA ST FL 3	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	000	19	8/5/2021	NON-COMPETING CONTINUATION	-$197,044
														Subtotal = -$197,044

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	BANNER HEALTH	901 E WILLETTA ST FL 3	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	000	19	3/3/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $2,054,622 )
2018	2018	BANNER HEALTH	901 E WILLETTA ST FL 3	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	001	19	5/2/2018	NON-COMPETING CONTINUATION	$0
2018	2018	BANNER HEALTH	901 E WILLETTA ST FL 3	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	000	19	4/20/2018	NON-COMPETING CONTINUATION	$2,054,622
														Subtotal = $2,054,622

Issue Date FY: 2017 ( Subtotal = $2,278,734 )
2017	2017	BANNER HEALTH	901 E WILLETTA ST FL 3	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	001	18	6/22/2017	NON-COMPETING CONTINUATION	$227,875
2017	2017	BANNER HEALTH	901 E WILLETTA ST FL 3	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	000	18	4/12/2017	NON-COMPETING CONTINUATION	$2,050,859
														Subtotal = $2,278,734

Issue Date FY: 2016 ( Subtotal = $2,308,936 )
2016	2016	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	001	17	6/7/2016	SUPPLEMENT FOR EXPANSION	$556,915
2016	2016	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	000	17	3/14/2016	NON-COMPETING CONTINUATION	$1,752,021
														Subtotal = $2,308,936

Issue Date FY: 2015 ( Subtotal = $1,775,239 )
2015	2015	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	000	16	3/31/2015	NON-COMPETING CONTINUATION	$1,775,239
														Subtotal = $1,775,239

Issue Date FY: 2014 ( Subtotal = $1,697,558 )
2014	2014	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	000	15	4/30/2014	COMPETING CONTINUATION	$1,697,558
														Subtotal = $1,697,558

Issue Date FY: 2012 ( Subtotal = $1,246,026 )
2012	2012	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	000	14	3/2/2012	NON-COMPETING CONTINUATION	$1,246,026
														Subtotal = $1,246,026

Issue Date FY: 2011 ( Subtotal = $1,286,593 )
2011	2011	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	001	13	6/9/2011	NON-COMPETING CONTINUATION	$81,873
2011	2011	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	000	13	3/2/2011	NON-COMPETING CONTINUATION	$1,204,720
														Subtotal = $1,286,593

Issue Date FY: 2010 ( Subtotal = $1,296,640 )
2010	2010	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	000	12	3/22/2010	NON-COMPETING CONTINUATION	$1,296,640
														Subtotal = $1,296,640

Issue Date FY: 2009 ( Subtotal = $1,335,485 )
2009	2009	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	000	11	3/26/2009	NON-COMPETING CONTINUATION	$1,335,485
														Subtotal = $1,335,485

Issue Date FY: 2008 ( Subtotal = $1,303,134 )
2008	2008	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	000	10	3/31/2008	OTHER REVISION	$1,303,134
														Subtotal = $1,303,134

Grand Total All Awards = $16,385,923

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Brain Imaging, APOE & the Preclinical Course of Alzheimer's Disease

Award Number: R01AG031581

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2008

PERIOD OF PERFORMANCE END DATE: 03/31/2021

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer