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Hemispheric differences in memory and language

Award Number: R01AG026308
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2005
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Hemispheric differences in memory and language - Project Summary The capacity to comprehend language lies at the core of a person's ability to gain information from the environment, perform everyday tasks, and maintain normal social relations. The critical role of the left cerebral hemisphere (LH) in supporting these processes has served as a paradigmatic example of neural specialization for higher cognitive functions. However, it is increasingly apparent that the right hemisphere (RH) also makes important, distinctive contributions to language comprehension. The aim of the proposed research is to delineate how processing resources distributed across the two cerebral hemispheres come together in real time to mediate language comprehension and afford memory for verbal material and how these processes and their underlying mechanisms change over the course of normal aging and in response to task demands. The proposal builds on a theoretical framework, based on neuropsychological, behavioral, and event-related brain potential (ERP) studies of language asymmetry, which asserts that LH and RH language comprehension differ because comprehension is cognitively and neurally integrated with language production only in the LH. Nineteen proposed experiments, conducted with both young and older adults, use event-related brain potentials (ERPs), often in combination with visual half-field presentation techniques to preferentially stimulate one hemisphere, to test the hypotheses that (1) the influence of predictive mechanisms increases with more preparation time and changes both the nature and amount of perceptual and semantic information that is gathered from incoming stimuli, (2) such prediction-driven differences in stimulus processing have important downstream consequences for both implicit and explicit memory, and (3) people differentially recruit language processing mechanisms depending on the perceived predictability and importance of the material, affecting comprehension and later memory. These experiments lay the foundation for an understanding of the computational and neurobiological roots of the complex and critical cognitive skill that is language and offer the promise to inform strategies for optimizing the comprehensibility and retention of verbal material – such as important health-related information.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2022	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Aging Research	000	15	12/1/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Aging Research	000	15	3/20/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $331,584 )
2022	2022	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Aging Research	000	15	7/11/2022	NON-COMPETING CONTINUATION	$331,584
														Subtotal = $331,584

Issue Date FY: 2021 ( Subtotal = $332,089 )
2021	2021	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Aging Research	000	14	5/17/2021	NON-COMPETING CONTINUATION	$332,089
														Subtotal = $332,089

Issue Date FY: 2020 ( Subtotal = $332,579 )
2020	2020	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Aging Research	000	13	5/22/2020	NON-COMPETING CONTINUATION	$332,579
														Subtotal = $332,579

Issue Date FY: 2019 ( Subtotal = $333,055 )
2019	2019	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Aging Research	000	12	5/22/2019	NON-COMPETING CONTINUATION	$333,055
														Subtotal = $333,055

Issue Date FY: 2018 ( Subtotal = $333,517 )
2018	2018	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST STE 364	URBANA	IL	61801	CHAMPAIGN	USA	Aging Research	001	11	8/27/2018	COMPETING CONTINUATION	$333,517
2018	2016	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST STE 364	URBANA	IL	61801	CHAMPAIGN	USA	Aging Research	000	10	3/27/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $333,517

Issue Date FY: 2016 ( Subtotal = $312,606 )
2016	2016	UNIVERSITY OF ILLINOIS BOARD OF TRUSTEES	109 COBLE HALL, 801 S WRIGHT S	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Aging Research	000	10	5/27/2016	EXTENSION WITH OR WITHOUT FUNDS	$312,606
														Subtotal = $312,606

Issue Date FY: 2015 ( Subtotal = $303,576 )
2015	2015	UNIVERSITY OF ILLINOIS BOARD OF TRUSTEES	109 COBLE HALL, 801 S WRIGHT S	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Aging Research	000	9	6/8/2015	NON-COMPETING CONTINUATION	$303,576
														Subtotal = $303,576

Issue Date FY: 2014 ( Subtotal = $0 )
2014	2013	UNIVERSITY OF ILLINOIS BOARD OF TRUSTEES	109 COBLE HALL, 801 S WRIGHT S	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Aging Research	000	8	7/11/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $296,081 )
2013	2013	UNIVERSITY OF ILLINOIS BOARD OF TRUSTEES	109 COBLE HALL, 801 S WRIGHT S	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Aging Research	000	8	8/19/2013	NON-COMPETING CONTINUATION	$296,081
														Subtotal = $296,081

Issue Date FY: 2012 ( Subtotal = $313,651 )
2012	2012	UNIVERSITY OF ILLINOIS BOARD OF TRUSTEES	109 COBLE HALL, 801 S WRIGHT S	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Aging Research	000	7	8/6/2012	NON-COMPETING CONTINUATION	$313,651
														Subtotal = $313,651

Issue Date FY: 2011 ( Subtotal = $313,980 )
2011	2011	UNIVERSITY OF ILLINOIS BOARD OF TRUSTEES	109 COBLE HALL, 801 S WRIGHT S	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Aging Research	000	6	9/12/2011	COMPETING CONTINUATION	$313,980
														Subtotal = $313,980

Issue Date FY: 2009 ( Subtotal = $249,116 )
2009	2009	UNIVERSITY OF ILLINOIS BOARD OF TRUSTEES	109 COBLE HALL, 801 S WRIGHT S	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Aging Research	000	5	6/17/2009	NON-COMPETING CONTINUATION	$249,116
														Subtotal = $249,116

Issue Date FY: 2008 ( Subtotal = $247,020 )
2008	2008	UNIVERSITY OF ILLINOIS BOARD OF TRUSTEES	109 COBLE HALL, 801 S WRIGHT S	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Aging Research	000	4	6/26/2008	NON-COMPETING CONTINUATION	$247,020
														Subtotal = $247,020

Issue Date FY: 2007 ( Subtotal = $250,863 )
2007	2007	UNIVERSITY OF ILLINOIS BOARD OF TRUSTEES	109 COBLE HALL, 801 S WRIGHT S	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Aging Research	000	3	6/29/2007	NON-COMPETING CONTINUATION	$250,863
														Subtotal = $250,863

Issue Date FY: 2006 ( Subtotal = $256,183 )
2006	2006	UNIVERSITY OF ILLINOIS BOARD OF TRUSTEES	109 COBLE HALL, 801 S WRIGHT S	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Aging Research	000	2	6/30/2006	NON-COMPETING CONTINUATION	$256,183
														Subtotal = $256,183

Issue Date FY: 2005 ( Subtotal = $280,054 )
2005	2005	UNIVERSITY OF ILLINOIS BOARD OF TRUSTEES	109 COBLE HALL, 801 S WRIGHT S	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Aging Research	000	1	7/14/2005	NEW	$280,054
														Subtotal = $280,054

Grand Total All Awards = $4,485,954

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Hemispheric differences in memory and language

Award Number: R01AG026308

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2005

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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