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Self-Regulation and Brain and Cognitive Health in Older Adults

Award Number: R01AG026307
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2006
PERIOD OF PERFORMANCE END DATE: 09/30/2024

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Self-Regulation and Brain and Cognitive Health in Older Adults - Summary The typical older adult experiences declines in brain structure and cognitive function, but these mean declines occur in the context of what can be very different individual trajectories. The purpose of this project is to measure individual differences and changes in self-regulation (control of thoughts, emotions, behaviors, and impulses) over time in older adults, and to link self-regulation to physical activity, inflammation, and trajectories of neurocognitive health relevant to development of Alzheimer’s disease. This is a competing renewal of this longitudinal study, which began in 2001 and received R01 funding in 2006, submitted by a research team with expertise in aging, self-regulation, exercise science, neuropsychology, neuroimaging, Alzheimer’s disease, and longitudinal design and analysis. The previous renewal period focused on relationships among facets of self-regulation and their relationship to immunological and cardiovascular health. The renewal continues assessment of these measures to provide continuity in this longitudinal dataset and adds innovation in the inclusion of repeated neuroimaging and assessment of infectious disease burden. Specifically, the aims of the study are: (1) to test the effects of facets of self-regulation (conscientiousness, self-regulation, executive cognitive function, and heart rate variability) on measures of neurocognitive health associated with aging and risk for Alzheimer’s disease; (2) to test the degree to which the relationship between self-regulation and neurocognitive health is mediated by physical activity and inflammation; (3) to test whether neurocognitive health associated with executive cognitive functions (e.g., dorsolateral frontal lobe volume) contributes to better self-regulation, higher physical activity, and lower inflammation; and (4) to test effects of infectious disease burden (latent viruses, Toxoplasma gondii) on self-regulation, inflammation, and neurocognitive health and risk for Alzheimer’s disease. At 6-month intervals, older adults (N = 175) will complete measures of self-reported self-regulation; executive cognitive functions including inhibition, shifting, and working memory; and resting HRV. Physical activity, BMI, and waist circumference will be measured at each visit. Blood draws will be synchronized with these visits, and assays performed on these samples will capture serum proinflammatory cytokines and antibodies against latent infections. The sample has follow-back data on many of these measures from 1-15 years, and an eligible subset (N = 90) will already have baseline neuroimaging. Neuroimaging will be repeated twice at 2-year intervals. This renewal will be innovative in its longitudinal assessment of a dynamic system that includes brain, behavior, and immunity; integration of neuroimaging measures with other domains of healthy and unhealthy aging; and multimodal assessment of neurocognitive health, including measures associated with risk for Alzheimer’s disease and other dementias: subjective cognitive health, cognitive function, volumetric imaging measures, connectivity, fractional anisotropy, and resting cerebral blood flow.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$483,171 )
2025	2022	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	000	15	2/4/2025	NON-COMPETING CONTINUATION	-$483,171
														Subtotal = -$483,171

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	000	15	11/7/2023	NON-COMPETING CONTINUATION	$0
2024	2022	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	001	15	4/8/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	000	15	3/17/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $637,768 )
2022	2022	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	000	15	5/13/2022	NON-COMPETING CONTINUATION	$637,768
														Subtotal = $637,768

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	000	14	7/29/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $702,482 )
2020	2020	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	000	14	7/22/2020	NON-COMPETING CONTINUATION	$702,482
														Subtotal = $702,482

Issue Date FY: 2019 ( Subtotal = $738,493 )
2019	2019	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	002	12	7/12/2019	SUPPLEMENT FOR EXPANSION	$5,516
2019	2019	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	001	13	4/1/2019	NON-COMPETING CONTINUATION	$700,712
2019	2019	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	000	12	11/30/2018	SUPPLEMENT FOR EXPANSION	$18,387
2019	2019	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	003	13	9/4/2019	NON-COMPETING CONTINUATION	$13,878
														Subtotal = $738,493

Issue Date FY: 2018 ( Subtotal = $670,841 )
2018	2018	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	000	12	4/17/2018	NON-COMPETING CONTINUATION	$670,841
2018	2017	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	003	11	4/19/2018	COMPETING CONTINUATION	$892,388
2018	2017	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	005	11	5/21/2018	COMPETING CONTINUATION	-$1,000
2018	2016	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	002	10	4/19/2018	EXTENSION WITH OR WITHOUT FUNDS	-$552,907
2018	2016	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	001	9	4/19/2018	SUPPLEMENT FOR EXPANSION	-$339,481
2018	2016	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	004	10	5/21/2018	EXTENSION WITH OR WITHOUT FUNDS	$1,000
														Subtotal = $670,841

Issue Date FY: 2017 ( Subtotal = $665,046 )
2017	2017	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	001	11	8/17/2017	COMPETING CONTINUATION	$665,046
2017	2016	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Aging Research	000	10	8/15/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $665,046

Issue Date FY: 2016 ( Subtotal = $841,317 )
2016	2016	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	105 KINKEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	Aging Research	000	9	4/14/2016	SUPPLEMENT FOR EXPANSION	$339,481
2016	2016	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	105 KINKEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	Aging Research	001	10	5/6/2016	EXTENSION WITH OR WITHOUT FUNDS	$501,836
														Subtotal = $841,317

Issue Date FY: 2015 ( Subtotal = $370,068 )
2015	2015	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	105 KINKEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	Aging Research	000	9	4/30/2015	NON-COMPETING CONTINUATION	$370,068
														Subtotal = $370,068

Issue Date FY: 2014 ( Subtotal = $383,314 )
2014	2014	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	105 KINKEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	Aging Research	000	8	7/18/2014	NON-COMPETING CONTINUATION	$383,314
														Subtotal = $383,314

Issue Date FY: 2013 ( Subtotal = $364,425 )
2013	2013	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	105 KINKEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	Aging Research	000	7	7/23/2013	NON-COMPETING CONTINUATION	$364,425
														Subtotal = $364,425

Issue Date FY: 2012 ( Subtotal = $438,854 )
2012	2012	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	105 KINKEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	Aging Research	002	6	7/20/2012	COMPETING CONTINUATION	$438,854
2012	2010	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	109 KINEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	Aging Research	000	5	4/19/2012	NON-COMPETING CONTINUATION	$0
2012	2010	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	109 KINEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	Aging Research	001	5	7/18/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $438,854

Issue Date FY: 2010 ( Subtotal = $320,976 )
2010	2010	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	109 KINEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	Aging Research	000	5	4/7/2010	NON-COMPETING CONTINUATION	$320,976
														Subtotal = $320,976

Issue Date FY: 2009 ( Subtotal = $328,924 )
2009	2009	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	109 KINEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	Aging Research	000	4	4/14/2009	NON-COMPETING CONTINUATION	$328,924
														Subtotal = $328,924

Issue Date FY: 2008 ( Subtotal = $334,878 )
2008	2008	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	109 KINEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	Aging Research	000	3	4/2/2008	NON-COMPETING CONTINUATION	$334,878
														Subtotal = $334,878

Issue Date FY: 2007 ( Subtotal = $348,573 )
2007	2007	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	109 KINEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	Aging Research	000	2	5/14/2007	NON-COMPETING CONTINUATION	$348,573
														Subtotal = $348,573

Issue Date FY: 2006 ( Subtotal = $360,568 ) (Continued on the next page)
Grand Total All Awards = $7,023,356

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Self-Regulation and Brain and Cognitive Health in Older Adults

Award Number: R01AG026307

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2006

PERIOD OF PERFORMANCE END DATE: 09/30/2024

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