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Alcohol use patterns and treatment, aging, and chronic conditions among people with HIV

Award Number: R01AA033289
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2031

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Alcohol use patterns and treatment, aging, and chronic conditions among people with HIV - Unhealthy alcohol use (UAU) is prevalent among people with HIV (PWH) and associated with poor outcomes including increased age-related chronic conditions. Many PWH, particularly PWH with UAU experience high rates of comorbidities at ages younger than those without HIV. Thus, there is an urgent need to focus on healthspan, defined as the time someone is healthy, not just alive, by identifying drivers of accelerated aging. The overall goal of this project is to determine how UAU and alcohol treatment influence age-related comorbidities and biological aging among PWH. This knowledge will guide targeted interventions to extend healthspan and reduce morbidity among aging PWH. The CFAR Network of Integrated Clinical Systems (CNICS), a longitudinal cohort of >50,000 PWH across 10 US sites, with comprehensive clinical data, adjudicated outcomes, genetic sequencing and detailed patient-reported outcomes (PROs) including nuanced alcohol assessment, provides an unparalleled platform to conduct this project. CNICS data allows inclusion of understudied outcomes such as physical and cognitive function; important potential consequences such as frailty and falls; and complex chronic diseases such as liver disease (e.g. MASLD: metabolic dysfunction- associated steatotic liver disease) that require measurement of chronic metabolic risk factors in addition to alcohol use and liver status. Capitalizing on CNICS infrastructure, we propose the following aims: 1. Evaluate the impact of UAU on age- related comorbidities among PWH including changes in alcohol use quantity and frequency, severity, lifetime alcohol use and threshold effects prioritizing outcomes in the Geriatric 5Ms Framework such as physical and cognitive function, including frailty and falls and HRQL; 2. Determine the uptake and impact of existing and emerging alcohol treatments among aging PWH using a target trial emulation framework including new and understudied treatments such as glucagon-like peptide-1 receptor agonists; 3. Determine differences in biological vs. chronological aging over time including the role of longitudinal patterns of alcohol use in driving higher biological age among PWH. Careful adjudication for key comorbidities and systematic longitudinal assessments of patient reported alcohol use, mental health symptoms, and context-based factors such as housing status and social support enables a rigorous approach to key questions on HIV, aging and alcohol that are highly responsive to NIH HIV priorities. Through robust CNICS alcohol phenotyping, longitudinal clinical data and epigenetic aging measures, this project will clarify how UAU contributes to chronic conditions and accelerated aging among PWH, identify meaningful treatment targets, and generate important evidence to guide implementation and dissemination of interventions that extend health span and improve outcomes among aging PWH.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $769,158 )
2026	2026	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Alcohol Research Programs	000	1	9/15/2026	NEW	$769,158
														Subtotal = $769,158

Grand Total All Awards = $769,158

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Alcohol use patterns and treatment, aging, and chronic conditions among people with HIV

Award Number: R01AA033289

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2031

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