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Improving diagnostic screening for fetal alcohol spectrum disorders (FASD) by broadening the reach of BRAIN-online

Award Number: R01AA033052
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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Improving diagnostic screening for fetal alcohol spectrum disorders (FASD) by broadening the reach of BRAIN-online - Project Summary/Abstract Fetal alcohol spectrum disorders (FASD) are one of the most common neurodevelopmental disorders, and people with FASD often experience challenges in multiple domains, including cognition and behavior. Accurate diagnosis is hindered by many factors, including challenges with reporting of prenatal alcohol exposure (PAE), high cost of evaluations, time commitments, limited accessibility, and lack of documentation and proper education among healthcare providers. Given these challenges, the published prevalence of FASD (1.1-5% of school-age children) is likely an underestimate. Accurate diagnosis and prevalence estimates are required for the development and implementation of intervention resources. Screening tools that are accessible, low-cost, and easy to administer can improve the efficiency of the diagnostic system by allowing prioritization of those individuals who have cognitive or behavioral impairment and will most benefit from an in-depth diagnostic evaluation, and perhaps provide alternative recommendations for others. To address these challenges, we developed BRAIN-online, a web-based screening tool designed to remotely measure cognitive and behavioral features of FASD. To increase the population served by this potentially powerful screening tool, BRAIN-online was translated into Spanish (BRAIN-online en Español). Examination of BRAIN-online en Español is necessary in children at risk for FASD and typically-developing comparison children (i.e., those children in regular school classrooms without histories of prenatal alcohol exposure). The overarching goal of this study is to improve diagnostic screening for FASD by broadening the reach of existing screening tools. We will achieve this goal by testing BRAIN-online en Español in youth at risk for FASD and a comparison group of typically developing children. Participants (first- to eighth-grade students) will be recruited from FASD diagnostic clinics and schools in San Diego County. Measures will include BRAIN-online en Español, in-person neuropsychological testing with parallel measures, and a parent survey assessing participant characteristics and history of PAE. Our research will examine the relationship between remote and in-person assessment, demonstrate the sensitivity and specificity of BRAIN-online en Español in detecting cognitive and behavioral effects in children at risk for FASD, and confirm our previous findings demonstrating the validity of BRAIN-online. Results of our study will increase accessibility to assessments and improve diagnostic screening of FASD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $435,083 )
2026	2026	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR	SAN DIEGO	CA	92182	SAN DIEGO	USA	Alcohol Research Programs	000	1	7/20/2026	NEW	$435,083
														Subtotal = $435,083

Grand Total All Awards = $435,083

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Improving diagnostic screening for fetal alcohol spectrum disorders (FASD) by broadening the reach of BRAIN-online

Award Number: R01AA033052

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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