Wednesday, September 17, 2025 9/17/2025

Hepatocyte FOXA3 in Alcohol-Associated Liver Disease

Award Number: R01AA032555
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/12/2025
PERIOD OF PERFORMANCE END DATE: 06/30/2030

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Hepatocyte FOXA3 in Alcohol-Associated Liver Disease - Project Summary Project Summary: Alcohol-associated liver disease (ALD) is the most prevalent type of chronic liver disease worldwide. ALD represents a spectrum of liver disorders resulting from alcohol use, ranging from alcohol- associated hepatic steatosis (i.e., alcoholic fatty liver) to more advanced forms, including alcohol-associated steatohepatitis (ASH)/hepatitis (AH) and cirrhosis (AC). Alcohol-associated hepatic steatosis is the result of the earliest response of the liver to alcohol abuse. So far, the mechanism underlying the pathogenesis of ALD remains to be fully understood. There are also limited options for the treatment of ALD. Our preliminary study shows that hepatic forkhead box A3 (FOXA3), a member of the winged-helix transcription factors, is reduced in patients or mice with ALD. In this project, we will investigate the role of hepatic FOXA3 in the development and progression of ALD. We will also characterize the underlying mechanisms. Gain- and loss-of-function approaches and state-of-the-art techniques will be used to investigate whether hepatic FOXA3 is a key player in the pathogenesis of ALD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $639,177 )
2025	2025	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Alcohol Research Programs	000	1	9/12/2025	NEW	$639,177
														Subtotal = $639,177

Grand Total All Awards = $639,177

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Hepatocyte FOXA3 in Alcohol-Associated Liver Disease

Award Number: R01AA032555

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/12/2025

PERIOD OF PERFORMANCE END DATE: 06/30/2030

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