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Sleep as a Mechanism of Change in Alcohol Use Outcomes among Heavy-Drinking Adults

Award Number: R01AA030525
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Sleep as a Mechanism of Change in Alcohol Use Outcomes among Heavy-Drinking Adults - PROJECT SUMMARY / ABSTRACT Heavy alcohol use is prevalent in the United States and results in significant physical and psychological burden. One in 10 adults in the United States reports binge drinking on a weekly basis, and few are willing to seek mental health treatment. Thus, additional strategies are needed to engage and treat individuals at risk for alcohol-related harm. Half of those who screen positive for hazardous drinking report clinically significant symptoms of insomnia. Insomnia tends to be less stigmatized than other mental health disorders, and it is one condition for which we have highly efficacious treatment. Thus, one potential strategy to engage individuals in mental health treatment and reduce the burden of alcohol use in the United States is to target insomnia. The proposed five-year R01 aims (1) to investigate daily associations between sleep and alcohol use, (2) to examine change in insomnia as a mediator of CBT-I effects on alcohol use outcomes and sex as a moderator of those effects, (3) to identify mechanisms linking change in insomnia to alcohol use outcomes, and (4) to evaluate CBT-I effects on cardiovascular outcomes. Heavy-drinking adults with insomnia will be randomly assigned to Cognitive Behavioral Therapy for Insomnia (CBT-I, n=112) or waitlist control (WLC, n=112). Outcomes will be assessed mid-treatment (after 3 sessions), at the end of the active intervention period (post- treatment), and at 1, 3, and 6 month follow-ups. Primary outcomes include insomnia severity, drinking quantity, and alcohol-related consequences. Data will be analyzed using multilevel models. The results of the proposed research will inform research and clinical practice by determining the extent to which sleep operates as a mechanism of alcohol behavior change. Its innovation lies in evaluation of insomnia not only as a gateway to mental health treatment, but also as a mechanism of improvement in alcohol-related consequences. This is consistent with NIAAA’s strategic plan to evaluate interventions that target sleep.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $429,577 )
2025	2025	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Alcohol Research Programs	000	3	7/31/2025	NON-COMPETING CONTINUATION	$429,577
														Subtotal = $429,577

Issue Date FY: 2024 ( Subtotal = $434,969 )
2024	2024	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Alcohol Research Programs	000	2	7/29/2024	NON-COMPETING CONTINUATION	$434,969
														Subtotal = $434,969

Issue Date FY: 2023 ( Subtotal = $522,286 )
2023	2023	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Alcohol Research Programs	000	1	8/29/2023	NEW	$522,286
														Subtotal = $522,286

Grand Total All Awards = $1,386,832

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Sleep as a Mechanism of Change in Alcohol Use Outcomes among Heavy-Drinking Adults

Award Number: R01AA030525

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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