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Alcohol Use Disorder and Cannabis: Testing Novel Harm Reduction Strategies

Award Number: R01AA029606
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/20/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Alcohol Use Disorder and Cannabis: Testing Novel Harm Reduction Strategies - Research Summary The prevalence of alcohol use disorders (AUDs) in the U.S. is approximately 12.7% and has shown a marked increase in recent years (Grant et al., 2017). Individuals with AUD often use cannabis, which may impact attempts to reduce or quit drinking. In the last six years, the United States has witnessed enormous changes concerning the public acceptance and availability of cannabis. Considering that cannabis has historically been the drug most often used by individuals with an AUD and considering the skyrocketing increase in availability of cannabis products, it is imperative for health care providers to understand how best to approach cannabis use with individuals who have an AUD and who want treatment. The central premise of the proposed research is that products with low THC and high CBD may be less harmful to AUD individuals who want to quit drinking, as compared to products with high THC only. It is hypothesized that individuals who switch from a high THC product to a low THC and higher CBD product will demonstrate superior outcomes compared to those individuals who do not switch. If the hypotheses are supported, the dissemination of the research would have an immediate effect on public health impact by educating patients and treatment providers about how to address the use of cannabis among individuals who want to quit or reduce alcohol consumption. To that end, individuals who currently use a high THC product and want to reduce or quit drinking will be randomly assigned to either the control condition (continue to use your current cannabis product as you wish) or the intervention condition (instruction to switch to low THC/high CBD product). Participants in the intervention condition choose the product and use as little or as much as they want during the study. Participants will be tested in the Mobile Pharmacology Laboratory at 6 and 12 week timepoints to determine the impact of these products on cue-elicited anxiety, cue-elicited alcohol craving, drinking outcomes, and biological markers of systemic inflammation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $501,086 )
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Alcohol Research Programs	000	5	4/10/2026	NON-COMPETING CONTINUATION	$501,086
														Subtotal = $501,086

Issue Date FY: 2025 ( Subtotal = $495,131 )
2025	2025	THE REGENTS OF THE UNIV. OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Alcohol Research Programs	000	4	7/10/2025	NON-COMPETING CONTINUATION	$495,131
														Subtotal = $495,131

Issue Date FY: 2024 ( Subtotal = $498,458 )
2024	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Alcohol Research Programs	001	3	5/15/2024	NON-COMPETING CONTINUATION	$49,845
2024	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Alcohol Research Programs	000	3	3/22/2024	NON-COMPETING CONTINUATION	$448,613
														Subtotal = $498,458

Issue Date FY: 2023 ( Subtotal = $496,806 )
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Alcohol Research Programs	000	2	3/21/2023	NON-COMPETING CONTINUATION	$496,806
														Subtotal = $496,806

Issue Date FY: 2022 ( Subtotal = $540,010 )
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Alcohol Research Programs	000	1	4/20/2022	NEW	$540,010
														Subtotal = $540,010

Grand Total All Awards = $2,531,491

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Alcohol Use Disorder and Cannabis: Testing Novel Harm Reduction Strategies

Award Number: R01AA029606

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/20/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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