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Prelimbic somatostatin peptide signaling in binge ethanol consumption

Award Number: R01AA029403
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/20/2022
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Prelimbic somatostatin peptide signaling in binge ethanol consumption - Project Summary Alcohol Use Disorder (AUD) is a complex psychiatric disorder with large societal and personal strain, involving many brain regions and cell types. Few effective treatments exist that specifically target the prevention of binge drinking. Understanding the underlying neurobiology of binge drinking is essential for preventing and treating this major public health problem. Ongoing work in our lab seeks to understand how somatostatin (SST) expressing GABAergic neurons in the prelimbic (PL) cortex, which have long been implicated in other neuropsychiatric disorders as an anti-depressive, resilience-conferring population of peptidergic neurons, may function as a therapeutic target for AUD. The overarching goal of this proposal is to understand how SST peptide signaling contributes to PL circuitry function, and how these pathways are modulated by binge alcohol consumption. Using a combination of electrophysiology, circuit mapping, fiber photometry, and behavior, we will explore three complementary but non-overlapping aims: we will demonstrate how SST modulates prelimbic pyramidal neurons, the specific outputs modulated by SST, and the overall behavioral phenotype of SST administration to the PL cortex. We will conduct these experiments during control conditions and in the context of binge drinking. Taken together, these experiments will determine the overall role of SST peptide effects on pathway-specific circuits of the PL cortex. In addition, we will establish the in vivo effects of SST peptide on alcohol consumption and anxiety-like behaviors, providing an overall mechanistic and functional characterization of SST in the PL cortex. These results will build upon our previous findings to elucidate the precise role of the SST peptide. Importantly, we expect these results to have the potential to inform new treatment targets for AUD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $313,846 )
2025	2025	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Alcohol Research Programs	000	4	5/1/2025	NON-COMPETING CONTINUATION	$313,846
														Subtotal = $313,846

Issue Date FY: 2024 ( Subtotal = $313,846 )
2024	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Alcohol Research Programs	001	3	5/10/2024	NON-COMPETING CONTINUATION	$31,384
2024	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Alcohol Research Programs	000	3	2/15/2024	NON-COMPETING CONTINUATION	$282,462
														Subtotal = $313,846

Issue Date FY: 2023 ( Subtotal = $621,435 )
2023	2023	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Alcohol Research Programs	000	2	2/10/2023	NON-COMPETING CONTINUATION	$316,694
2023	2023	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Alcohol Research Programs	001	2	4/5/2023	SUPPLEMENT FOR EXPANSION	$304,741
														Subtotal = $621,435

Issue Date FY: 2022 ( Subtotal = $346,721 )
2022	2022	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Alcohol Research Programs	000	1	4/18/2022	NEW	$346,721
2022	2022	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Alcohol Research Programs	001	1	5/2/2022	NEW	$0
														Subtotal = $346,721

Grand Total All Awards = $1,595,848

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Prelimbic somatostatin peptide signaling in binge ethanol consumption

Award Number: R01AA029403

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/20/2022

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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