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Neurodevelopmental Effects of Prenatal Exposure to Maternal Drinking, Smoking and Adverse Psychosocial Factors: Deep Phenotyping of Infant CNS and ANS Function

Award Number: R01AA029159
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Neurodevelopmental Effects of Prenatal Exposure to Maternal Drinking, Smoking and Adverse Psychosocial Factors: Deep Phenotyping of Infant CNS and ANS Function - PROJECT SUMMARY Alcohol use and smoking during pregnancy often occur in the context of maternal anxiety and depression. However, little is known regarding how different combinations of maternal alcohol use, smoking, and psychiatric symptoms interact to alter early central and autonomic nervous system (CNS, ANS) development and subsequent neurobehavioral outcomes in offspring. To better understand these relationships, this grant proposes to comprehensively characterize maternal alcohol, smoking, depression, and anxiety patterns during pregnancy via machine learning and artificial intelligence methodologies; to perform deep phenotyping of electrocortical and physiological data from infants; to test the overall hypothesis that physiology-derived measures mediate the relationship between maternal prenatal exposures and subsequent child neurodevelopmental outcomes. To accomplish these goals, this research proposes to use existing data from the completed Safe Passage Study conducted by the NIH funded Prenatal Alcohol in SIDS and Stillbirth (PASS) Network and from recently completed follow-up studies which enrolled subsets of the PASS participants. PASS cohort participants are from geographically and socio-economically diverse regions in South Africa and the Northern Plains of the United States. The extant PASS database comprises a detailed documentation of daily alcohol and smoking exposure and prenatal depression/anxiety assessments collected for 10,325 maternal/infant dyads and more than 1,000 variables which provide extensive information on maternal-fetal-infant medical history, demographics, and socio-economic status. These exposure data will be analyzed in relation to neonatal CNS/ANS deep phenotyping profiles derived from the analysis of 3,355 infant electroencephalograms (EEG) and electrocardiogram (ECG) data recorded either at birth or at one month of age. The extant neurobehavioral outcomes data were collected in four distinct cohorts of participants originally enrolled in PASS and followed up at 12 months (n=849) and 24-37 months of age (n=667). The follow-up study datasets contain item-level data, sub-test raw scores, and scaled-scores for the Mullen scales of early learning, the Parent Report of Children’s Abilities-Revised (PARCA-R), the Bayley scales of infant development III screening test and the Modified Checklist for Autism in Toddlers Revised with Follow up (M-CHAT-R/F). The proposed approach is expected to elucidate mechanisms of suboptimal neurodevelopment and resilience, and ultimately inform screenings for at-risk groups. Additionally, the proposed comprehensive deep phenotyping is intended to identify markers that are potential mediators of the relationship between prenatal exposures and outcomes. We anticipate that our findings will capitalize on the geocultural diversity of our cohorts and provide meaningful information associated with health disparities in underrepresented populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Alcohol Research Programs	000	3	1/9/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $417,778 )
2024	2024	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Alcohol Research Programs	000	3	4/9/2024	NON-COMPETING CONTINUATION	$376,000
2024	2024	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Alcohol Research Programs	001	3	5/21/2024	NON-COMPETING CONTINUATION	$41,778
														Subtotal = $417,778

Issue Date FY: 2023 ( Subtotal = $417,778 )
2023	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Alcohol Research Programs	000	2	3/30/2023	NON-COMPETING CONTINUATION	$417,778
														Subtotal = $417,778

Issue Date FY: 2022 ( Subtotal = $431,220 )
2022	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Alcohol Research Programs	000	1	3/23/2022	NEW	$431,220
														Subtotal = $431,220

Grand Total All Awards = $1,266,776

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Neurodevelopmental Effects of Prenatal Exposure to Maternal Drinking, Smoking and Adverse Psychosocial Factors: Deep Phenotyping of Infant CNS and ANS Function

Award Number: R01AA029159

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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