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Using Neuroeconomics to Characterize State-Based Increases and Decreases in Alcohol Value

Award Number: R01AA027255
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/05/2019
PERIOD OF PERFORMANCE END DATE: 07/31/2024

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Using Neuroeconomics to Characterize State-Based Increases and Decreases in Alcohol Value - PROJECT SUMMARY/ABSTRACT Neuroeconomics integrates concepts and methods from psychology, economics, and cognitive neuroscience to understand the neurobiological foundations of decision making, and has been increasingly applied to understanding alcohol use disorder (AUD). A novel application of neuroeconomics is the study of alcohol demand, or the value of alcohol as measured by cost-benefit preferences. Alcohol demand paradigms have considerable ecological validity by measuring the impact of internal and external influences on alcohol decision-making, such as price, environmental cues, affective states, or external contingencies. Behaviorally, alcohol demand is elevated among individuals with higher levels of alcohol misuse and predicts treatment response. Alcohol demand also exhibits state-like properties, including increases following exposure to alcohol-related cues and decreases in the presence of significant next-day responsibilities. The overall goal of the proposed studies is to characterize the neural activity that subserves these established behavioral findings using a novel functional MRI paradigm. The first aim is to examine the patterns of neural activation underlying increases in the value of alcohol in response to alcohol cues. To do so, the first study will use a within-subjects design to identify differences in neural activity associated with demand decisions following a validated in- scanner cue exposure protocol consisting of exposure to neutral beverage cues and exposure to alcohol beverage cues in a sample of adult heavy drinkers. The second aim is to investigate the changes in neural activity associated with decreases in the value of alcohol in response to next day responsibilities. To do so, a second study will use a within-subjects design, comparing demand-related neural activity following a standard instructional set and an instructional set that imposes a significant work-related responsibility the next day. Using a novel neuroeconomics approach, these studies combine a highly ecologically-valid alcohol demand paradigm with two experimental manipulations that model clinically-relevant influences on drinking decisions. Studying these contextual influences may help clarify the neural signatures that underlie drinking moderation vs. unconstrained drinking, and how these processes are impacted by AUD. If successful, these studies will provide a foundation for examining neural predictors of successful recovery or response to treatment vs. relapse. More broadly, findings from these studies have high potential to significantly enhance the clinical relevance of alcohol neuroscience.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $213,735 )
2023	2023	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Alcohol Research Programs	002	5	7/31/2023	NON-COMPETING CONTINUATION	$213,735
2023	2020	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Alcohol Research Programs	001	2	3/16/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$63,940
2023	2019	MCMASTER UNIVERSITY	1280 MAIN ST W	HAMILTON	ON			CAN	Alcohol Research Programs	000	1	3/16/2023	NEW	-$63,940
														Subtotal = $213,735

Issue Date FY: 2022 ( Subtotal = $251,137 )
2022	2022	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Alcohol Research Programs	000	4	8/3/2022	NON-COMPETING CONTINUATION	$251,137
2022	2020	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Alcohol Research Programs	002	2	8/16/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$78,850
2022	2019	MCMASTER UNIVERSITY	1280 MAIN ST W SUITE 20	HAMILTON	ON			CAN	Alcohol Research Programs	001	1	8/16/2022	NEW	$78,850
														Subtotal = $251,137

Issue Date FY: 2021 ( Subtotal = $268,113 )
2021	2021	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Alcohol Research Programs	002	3	7/22/2021	NON-COMPETING CONTINUATION	$268,113
2021	2020	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Alcohol Research Programs	001	2	6/8/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$78,850
2021	2019	MCMASTER UNIVERSITY	1280 MAIN ST W SUITE 20	HAMILTON	ON			CAN	Alcohol Research Programs	000	1	6/8/2021	NEW	-$78,850
														Subtotal = $268,113

Issue Date FY: 2020 ( Subtotal = $282,618 )
2020	2020	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Alcohol Research Programs	001	2	9/11/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$282,618
2020	2019	MCMASTER UNIVERSITY	1280 MAIN ST W SUITE 20	HAMILTON	ON	L8S 4L8		CAN	Alcohol Research Programs	000	1	9/11/2020	NEW	$0
														Subtotal = $282,618

Issue Date FY: 2019 ( Subtotal = $186,085 )
2019	2019	MCMASTER UNIVERSITY	1280 MAIN ST W SUITE 20	HAMILTON	ON	L8S 4L8		CAN	Alcohol Research Programs	000	1	8/2/2019	NEW	$186,085
														Subtotal = $186,085

Grand Total All Awards = $1,201,688

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Using Neuroeconomics to Characterize State-Based Increases and Decreases in Alcohol Value

Award Number: R01AA027255

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/05/2019

PERIOD OF PERFORMANCE END DATE: 07/31/2024

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