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Examining the Impact of Stress on the Emotionally Reinforcing Properties of Alcohol in Heavy Social Drinkers: A Multimodal Investigation Integrating Laboratory and Ambulatory Methods

Award Number: R01AA025969
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Examining the Impact of Stress on the Emotionally Reinforcing Properties of Alcohol in Heavy Social Drinkers: A Multimodal Investigation Integrating Laboratory and Ambulatory Methods - Alcohol’s ability to improve mood in the face of stress is among its most prized reinforcing properties, long held by researchers to be of critical importance for the understanding of the etiology of alcohol use disorder (AUD). Drinkers overwhelmingly report that the mood-enhancement they gain from alcohol is most pronounced in the context of stress, and individuals who report higher levels of stress relief from alcohol are at risk for developing AUD. But attempts to capture this key element of alcohol reinforcement using experimental methods have yielded strikingly inconsistent results. One remarkable feature of the extant experimental literature is that, in attempting to capture alcohol’s stress-relieving effects, researchers have strayed far outside the range of stressors typically encountered in everyday drinking settings, contexts that are overwhelmingly social in nature. Here, we harness the power of stressful stimuli that emerge naturally within everyday contexts, focusing on social novelty as a compound stress-trigger ubiquitous to real-world heavy drinking settings. Building on our prior work indicating enhanced alcohol reward in novel compared with familiar social context, together with pilot findings pointing to potential links between social novelty and hazardous patterns of drinking, we draw on innovative methods and measures to further build the understanding of social-contextual factors driving consumption. Specifically, we leverage multi-participant neuroimaging recording arrays (i.e., hyperscanning) to pinpoint both inter- and intra-brain processes underlying alcohol reinforcement, a mechanistic analysis we complement with ambulatory and longitudinal methods for tracing real world patterns of consumption. Participants (N=240) will attend two experimental laboratory sessions, on one of which they will consume alcohol and on the other a control beverage. Participants will complete tasks in the company of either a stranger or familiar individual while EEG is recorded from both participants simultaneously. Participants will also engage in a 14-day ambulatory assessment period during which drinking will be assessed continuously via transdermal alcohol biosensor while social context is explored via in-vivo photographic image- capture methods. Finally, longitudinal changes in hazardous drinking and AUD symptoms will be assessed for 24 months post-baseline. The aims of the project are to: 1) Explore diminished threat sensitivity and enhanced social engagement as mechanisms driving alcohol reward in novel social context; 2) Examine social reward- attentive processes as well as social-contextual novelty as predictors of hazardous drinking and AUD. The proposed research contributes to the understanding of AUD by addressing one of the most fundamental questions in the alcohol literature—the question of why people drink. Further, representing a critical step towards building a contextually-informed, mechanistically precise model of AUD etiology, the proposed study might have a variety of key implications including for refining harm-reduction and prevention programs, reducing rates of relapse, informing public health policy, and the early identification of those at risk.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $525,929 )
2024	2024	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Alcohol Research Programs	002	7	6/19/2024	NON-COMPETING CONTINUATION	$525,929
2024	2023	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Alcohol Research Programs	001	6	3/26/2024	COMPETING CONTINUATION	$248,542
2024	2021	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Alcohol Research Programs	000	5	3/26/2024	NON-COMPETING CONTINUATION	-$248,542
														Subtotal = $525,929

Issue Date FY: 2023 ( Subtotal = $523,246 )
2023	2023	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Alcohol Research Programs	000	6	8/15/2023	COMPETING CONTINUATION	$523,246
														Subtotal = $523,246

Issue Date FY: 2021 ( Subtotal = $303,438 )
2021	2021	UNIVERSITY OF ILLINOIS	352 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Alcohol Research Programs	000	5	6/9/2021	NON-COMPETING CONTINUATION	$303,438
														Subtotal = $303,438

Issue Date FY: 2020 ( Subtotal = $303,954 )
2020	2020	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Alcohol Research Programs	000	4	6/12/2020	NON-COMPETING CONTINUATION	$303,954
														Subtotal = $303,954

Issue Date FY: 2019 ( Subtotal = $304,456 )
2019	2019	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Alcohol Research Programs	000	3	5/27/2019	NON-COMPETING CONTINUATION	$304,456
														Subtotal = $304,456

Issue Date FY: 2018 ( Subtotal = $304,942 )
2018	2018	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST STE 364	URBANA	IL	61801	CHAMPAIGN	USA	Alcohol Research Programs	000	2	5/16/2018	NON-COMPETING CONTINUATION	$304,942
														Subtotal = $304,942

Issue Date FY: 2017 ( Subtotal = $305,414 )
2017	2017	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST STE 364	URBANA	IL	61801	CHAMPAIGN	USA	Alcohol Research Programs	000	1	8/30/2017	NEW	$305,414
														Subtotal = $305,414

Grand Total All Awards = $2,571,379

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Examining the Impact of Stress on the Emotionally Reinforcing Properties of Alcohol in Heavy Social Drinkers: A Multimodal Investigation Integrating Laboratory and Ambulatory Methods

Award Number: R01AA025969

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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