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Predicting Alcohol Use and Alcohol Use Disorder Symptoms from Subjective Responses to Alcohol in a Laboratory Social Setting

Award Number: R01AA025936
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract The proposed project is a new submission by a New and Early Stage Investigator for an R01 (Funding Opportunity Announcement PAR-16-260). The vast majority of alcohol use takes place in social settings, yet nearly all human experimental research has administered alcohol to individuals in isolation. This research setting dampens reports of alcohol stimulation, increased positive affect, and decreased negative affect, and it makes it impossible to measure many of the subjectively pleasant social effects of alcohol that confer increased risk for alcohol use disorder (AUD) (e.g., increased sociability, decreased social anxiety). Notably, to date, laboratory subjective responses to alcohol (SRA) in isolation have accounted for between just 4% and 6% of the variance in future AUD symptoms. The proposed study will be the first to examine the effects of alcohol in social groups across a number of domains hypothesized to mediate alcohol use, and to test whether these responses can better predict the development of AUD symptoms. Further, this study will be the first to examine intermediate real-world drinking experiences using ecological momentary assessment (EMA) methods in order to evaluate how lab-based SRA translate to risk processes outside of the laboratory. Three-hundred-eighty-four heavy drinkers (50% female; aged 21-25) will be assembled into 128 three- person groups. All members of each group will drink over 36-min a moderate dose of alcohol (males: 0.82 g/kg; females: 0.74 g/kg) or a placebo beverage; SRA and social reward (e.g., social bonding) will be assessed using a broad range of measures across multiple response systems (e.g., self-reports, observational measures of smiling and speech patterns). Drinking behavior, SRA, and acute alcohol- related problems will be assessed in daily life during three subsequent EMA bursts, and AUD symptoms will be assessed at baseline and at 12-month follow-up. We predict that participants drinking alcohol will experience more stimulation/positive affect, craving, and social reward (e.g., social bonding) and less sedation, negative affect, and social discomfort on the ascending limb of the blood alcohol curve, measured across multiple response systems, than those drinking placebo. Further, we predict that these lab-based SRA and social reward indices will be clinically meaningful—that is, we expect that they will prospectively predict SRA, heavier alcohol use, and more acute alcohol-related problems in daily life, and more AUD symptoms at 12-month follow-up. Finally, we predict that SRA in daily life will mediate the link between laboratory SRA and AUD symptoms. We will also test whether individuals at risk for AUD (e.g., due to personality, genetics) are especially sensitive to alcohol's effects in the lab and in daily life and whether this predicts heavier alcohol use and the development of more AUD symptoms over time. This work, by developing a laboratory social drinking paradigm that predicts real-world alcohol responses and AUD risk, can serve as the next generation model for identifying lab-based predictors for future AUD symptoms.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Alcohol Research Programs	000	5	11/8/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $165,673 )
2022	2022	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Alcohol Research Programs	000	5	5/20/2022	SUPPLEMENT FOR EXPANSION	$165,673
2022	2021	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Alcohol Research Programs	001	5	5/26/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $165,673

Issue Date FY: 2021 ( Subtotal = $292,248 )
2021	2021	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Alcohol Research Programs	000	5	5/20/2021	NON-COMPETING CONTINUATION	$292,248
														Subtotal = $292,248

Issue Date FY: 2020 ( Subtotal = $406,027 )
2020	2020	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Alcohol Research Programs	000	4	6/9/2020	NON-COMPETING CONTINUATION	$406,027
														Subtotal = $406,027

Issue Date FY: 2019 ( Subtotal = $384,549 )
2019	2019	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Alcohol Research Programs	000	3	5/14/2019	NON-COMPETING CONTINUATION	$384,549
														Subtotal = $384,549

Issue Date FY: 2018 ( Subtotal = $383,011 )
2018	2018	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Alcohol Research Programs	000	2	5/10/2018	NON-COMPETING CONTINUATION	$383,011
														Subtotal = $383,011

Issue Date FY: 2017 ( Subtotal = $433,163 )
2017	2017	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Alcohol Research Programs	000	1	9/7/2017	NEW	$433,163
														Subtotal = $433,163

Grand Total All Awards = $2,064,671

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Predicting Alcohol Use and Alcohol Use Disorder Symptoms from Subjective Responses to Alcohol in a Laboratory Social Setting

Award Number: R01AA025936

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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