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Serial Nights of Alcohol Administration: Impact on Sleep and Next-Day Neurocognitive Function and Alertness

Award Number: R01AA025593
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Serial Nights of Alcohol Administration: Impact on Sleep and Next-Day Neurocognitive Function and Alertness - Summary Abstract Given the scope of the alcohol problem in the US, our interdisciplinary team has come together with two distinct scientific outlooks to examine the interaction of alcohol and sleep with neurocognitive performance and whether this interaction may help identify strategies to improve treatment outcomes for alcohol use disorders (AUD). AUD psychosocial treatments have been developed that span a number of approaches, but all such interventions depend on intact cognitive function to be effective. Many aspects of neurocognitive function required to learn and apply psychosocial skills, however, are adversely affected by repeated alcohol use and sleep disturbance. Effective use of the skills taught by psychotherapy requires neurocognitive functioning consistent with 1) learning skills, 2) assessing the need for skills both ahead of time and in the moment, and 3) implementing skills when needed. The combination of continued heavy alcohol use and associated sleep disruption likely prevents patients' realizations of the full benefits of effective psychosocial interventions. Approaches to improving sleep in the context of AUD and psychosocial interventions must target aspects of sleep most predictive of impaired neurocognitive functioning, particularly under conditions of repeated alcohol use. The effects of serial (i.e., multi-night) alcohol administration and sleep disruption and their interactive effect on neurocognitive function are unknown. Furthermore, there is a notable lack of alcohol and sleep- related laboratory research in mature adults (defined as 35-50), including assessment of potential male-female differences. Our approach is to test sleep and next-day neurocognitive effects in mature heavy-drinking adults after administering alcohol (targeted BAC of .1g%) on consecutive nights in a controlled laboratory setting under three sleep conditions: nominal (drinking followed by 8.5 h sleep on “usual sleep schedule”), delayed (drinking followed by 8.5 h sleep 3 h later than usual sleep), and delayed/restricted (drinking followed by 5.5 h sleep 3 h later than usual). These study conditions provide the opportunity to explore neurocognitive consequences of alcohol's effects on sleep, but also to pursue fundamental research questions. These studies will 1) assess the influence of 3 nights' alcohol administration under 3 sleep conditions (nominal, delayed, delayed/restricted) on next-day neurocognitive performance and alertness/sleepiness; 2) assess the associations among serial nightly alcohol administration, rate of alcohol metabolism, and 3 sleep conditions and sleep physiology; and 3) we will explore sleep and alcohol variables for mechanistic influences on next- day neurocognitive functioning.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$1,250 )
2023	2021	BRADLEY EMMA PENDLETON HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Alcohol Research Programs	000	5	9/18/2023	NON-COMPETING CONTINUATION	-$1,250
														Subtotal = -$1,250

Issue Date FY: 2021 ( Subtotal = $448,956 )
2021	2021	EMMA PENDLETON BRADLEY HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Alcohol Research Programs	000	5	3/30/2021	NON-COMPETING CONTINUATION	$448,956
														Subtotal = $448,956

Issue Date FY: 2020 ( Subtotal = $448,956 )
2020	2020	EMMA PENDLETON BRADLEY HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Alcohol Research Programs	000	4	3/19/2020	NON-COMPETING CONTINUATION	$448,956
														Subtotal = $448,956

Issue Date FY: 2019 ( Subtotal = $449,379 )
2019	2019	EMMA PENDLETON BRADLEY HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Alcohol Research Programs	000	3	3/26/2019	NON-COMPETING CONTINUATION	$449,379
														Subtotal = $449,379

Issue Date FY: 2018 ( Subtotal = $452,670 )
2018	2018	EMMA PENDLETON BRADLEY HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Alcohol Research Programs	001	2	5/24/2018	NON-COMPETING CONTINUATION	$45,267
2018	2018	BRADLEY, EMMA PENDLETON HOSPITAL	1011 VETERANS MEMORIAL PK	RIVERSIDE	RI	02915	PROVIDENCE	USA	Alcohol Research Programs	000	2	3/30/2018	NON-COMPETING CONTINUATION	$407,403
														Subtotal = $452,670

Issue Date FY: 2017 ( Subtotal = $455,919 )
2017	2017	BRADLEY, EMMA PENDLETON HOSPITAL	1011 VETERANS MEMORIAL PK	RIVERSIDE	RI	02915	PROVIDENCE	USA	Alcohol Research Programs	000	1	4/7/2017	NEW	$455,919
														Subtotal = $455,919

Grand Total All Awards = $2,254,630

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Serial Nights of Alcohol Administration: Impact on Sleep and Next-Day Neurocognitive Function and Alertness

Award Number: R01AA025593

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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