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Precision Medicine and Recovery in a Telehealth Treatment Program for Alcohol Use Disorder

Award Number: R01AA022328
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/05/2013
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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Precision Medicine and Recovery in a Telehealth Treatment Program for Alcohol Use Disorder - Project Summary/Abstract Alcohol use disorder (AUD) is prevalent and costly, and associated with significant morbidity and mortality. Yet, despite the availability of modestly effective treatments, many individuals do not seek treatment because they do not want to abstain from alcohol. Recent studies in population-based and clinical samples indicate significant health benefit from drinking reductions and there is an accumulation of evidence that drinking reductions are both achievable and associated with improvements in functioning among individuals with AUD. Examining whether drinking reductions can be associated with meaningful recovery of functioning is critically important because expanding the definition of recovery to include non-abstinent recoveries and functional outcomes could increase acceptability of non-abstinent treatment goals among providers and policy-makers, increase treatment seeking among those with AUD who are not willing to abstain completely, and ultimately reduce the public health burden of untreated AUD. Aligned with an expanded definition of recovery, the National Institute on Alcohol Abuse and Alcoholism (NIAAA) has proposed a new operational definition of recovery defined as: remission from AUD, cessation of heavy drinking, and improvements in functioning and well-being. NIAAA has also moved the field forward by proposing the addictions neuroclinical assessment (ANA) to provide a framework for understanding AUD in terms of psychological and biological constructs. The ANA proposes that AUD develops, progresses, and is maintained because of heightened incentive salience for alcohol, greater negative emotionality, and/or impairments in executive functioning. Reducing incentive salience and negative emotionality, and improving executive functioning may also be associated with recovery from AUD. The ANA was proposed with the goal of improving efforts at precision medicine for AUD. As such, it is critically important that clinical assessments based on the ANA be studied and validated in order to inform clinical decision making and precision medicine initiatives for AUD, ideally in a heterogeneous group of people in treatment for AUD. Building on our prior work examining drinking reductions, the ANA, and recovery, this study will replicate and extend this research in a real-world treatment setting. The overarching goal of this continuing program of research is to aid in AUD precision medicine initiatives by examining real-world effectiveness of medication treatment in supporting drinking reductions, as well as studying AUD phenotypes, characterized using the ANA, and AUD recovery. To achieve the study aims, we will recruit a new sample of individuals who are enrolled in nationwide telehealth treatment program for AUD and follow them for 18- months after initiation of an AUD treatment episode. The results from this study will be directly applicable to clinical practice and future research on AUD precision medicine. This work addresses NIH priorities to replicate previous findings and NIAAA priorities to improve outcomes in recovery. We will also study implementation of phenotyping approaches to inform precision medicine in real-world clinical practice.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $688,939 )
2026	2026	UNIVERSITY OF NEW MEXICO	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Alcohol Research Programs	000	8	7/8/2026	COMPETING CONTINUATION	$688,939
														Subtotal = $688,939

Issue Date FY: 2024 ( Subtotal = -$20,045 )
2024	2022	UNIVERSITY OF NEW MEXICO	1700 LOMAS BLVD NE STE 2200	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Alcohol Research Programs	000	7	8/27/2024	NON-COMPETING CONTINUATION	-$20,045
														Subtotal = -$20,045

Issue Date FY: 2022 ( Subtotal = $340,678 )
2022	2022	UNIVERSITY OF NEW MEXICO, THE	1700 LOMAS BLVD NE STE 2200	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	000	7	3/31/2022	NON-COMPETING CONTINUATION	$340,678
														Subtotal = $340,678

Issue Date FY: 2021 ( Subtotal = $340,853 )
2021	2021	UNIVERSITY OF NEW MEXICO, THE	1700 LOMAS BLVD NE STE 2200	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	000	6	3/30/2021	NON-COMPETING CONTINUATION	$340,853
														Subtotal = $340,853

Issue Date FY: 2020 ( Subtotal = $341,014 )
2020	2020	UNIVERSITY OF NEW MEXICO	1700 LOMAS BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	000	5	3/20/2020	NON-COMPETING CONTINUATION	$341,014
														Subtotal = $341,014

Issue Date FY: 2019 ( Subtotal = $376,010 )
2019	2019	UNIVERSITY OF NEW MEXICO	1700 LOMAS BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	000	4	4/12/2019	COMPETING CONTINUATION	$376,010
														Subtotal = $376,010

Issue Date FY: 2018 ( Subtotal = -$295 )
2018	2015	UNIVERSITY OF NEW MEXICO	1700 LOMAS BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	000	3	6/15/2018	NON-COMPETING CONTINUATION	-$295
														Subtotal = -$295

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	UNIVERSITY OF NEW MEXICO	1700 LOMAS BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	000	3	8/1/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $328,994 )
2015	2015	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Alcohol Research Programs	000	3	7/10/2015	NON-COMPETING CONTINUATION	$328,994
														Subtotal = $328,994

Issue Date FY: 2014 ( Subtotal = $328,994 )
2014	2014	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Alcohol Research Programs	000	2	7/14/2014	NON-COMPETING CONTINUATION	$328,994
														Subtotal = $328,994

Issue Date FY: 2013 ( Subtotal = $313,841 )
2013	2013	UNIVERSITY OF NEW MEXICO (THE)	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Alcohol Research Programs	000	1	8/5/2013	NEW	$313,841
														Subtotal = $313,841

Grand Total All Awards = $3,038,983

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Precision Medicine and Recovery in a Telehealth Treatment Program for Alcohol Use Disorder

Award Number: R01AA022328

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/05/2013

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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