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EFFECTS OF HEAVY ALCOHOL ABUSE ON ADOLESCENT BRAIN STRUCTURE AND FUNCTION

Award Number: R01AA016303
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/10/2007
PERIOD OF PERFORMANCE END DATE: 05/31/2012

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EFFECTS OF HEAVY ALCOHOL ABUSE ON ADOLESCENT BRAIN STRUCTURE AND FUNCTION - DESCRIPTION (provided by applicant): Relatively little is known about alcohol's effects in adolescence, a critical stage of human development. This is true despite the facts that: 1) the majority of individuals began experimenting with alcohol as teenagers, 2) drinking beginning in adolescence is one of the most powerful predictors of later alcohol abuse, and 3) in adolescence, there are changes in the areas of the brain that modulate drug reinforcement. In addition, most studies of the impact of alcohol dependence on the brain have examined individuals in treatment. Such samples represent a small proportion of alcoholics in the general population, and we have shown that treated adult alcoholics are not a representative sample of the general population of adult alcoholics with more intense early trajectory of alcohol consumption and with greater comorbid psychopathology and abnormal psychological functioning. Until proven otherwise, a reasonable assumption is that adolescents in treatment for alcohol use disorders (AUDs) are also heavier drinkers with more comorbidities than untreated adolescents with AUDs in the general population. For this reason, it is crucially important to study adolescent alcohol abusers in the community in order to understand the effects of alcohol abuse on the adolescent brain in the population at large. Moreover, it is important to study community adolescents with AUDs, but without other substance use disorders (SUDs). To do otherwise, would make it impossible to disentangle the effects of AUDs from those of other SUDs on brain structure and function. This goal has not been achievable in the United States, because the vast majority of adolescents with AUDs also have other SUDs. In the Cape Town region of South Africa, a unique opportunity to study 'pure' adolescent AUDs exists (we have documented this in a pilot study). We propose to recruit and study 100 such adolescents with AUDs (12 - 18 years of age, half males and half females), and 100 light/non-drinker age and gender matched controls, all without other SUDs or current diagnosable comorbid psychopathology. Subjects will be studied in four domains: psychological functioning, neuropsychological functioning, brain structure, and electrophysiological measures of brain function. We will be uniquely able to isolate the effects of AUDs on brain structure and function in adolescence.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2011 ( Subtotal = $508,907 )
2011	2011	NEUROBEHAVIORAL RESEARCH, INC	201 Tamal Vista Blvd # 200	Corte Madera	CA	94925	MARIN	USA	Alcohol Research Programs	000	5	6/8/2011	NON-COMPETING CONTINUATION	$508,907
														Subtotal = $508,907

Issue Date FY: 2010 ( Subtotal = $564,052 )
2010	2010	NEUROBEHAVIORAL RESEARCH, INC	201 Tamal Vista Blvd # 200	Corte Madera	CA	94925	MARIN	USA	Alcohol Research Programs	000	4	6/1/2010	NON-COMPETING CONTINUATION	$564,052
														Subtotal = $564,052

Issue Date FY: 2009 ( Subtotal = $394,656 )
2009	2009	NEUROBEHAVIORAL RESEARCH, INC	201 Tamal Vista Blvd # 200	Corte Madera	CA	94925	MARIN	USA	Alcohol Research Programs	001	3	6/25/2009	NON-COMPETING CONTINUATION	$553,855
2009	2008	NEUROBEHAVIORAL RESEARCH, INC	201 Tamal Vista Blvd # 200	Corte Madera	CA	94925	MARIN	USA	Alcohol Research Programs	000	2	6/16/2009	NON-COMPETING CONTINUATION	-$159,199
														Subtotal = $394,656

Issue Date FY: 2008 ( Subtotal = $697,630 )
2008	2008	NEUROBEHAVIORAL RESEARCH, INC	45 GABLE COURT	SAN RAFAEL	CA	94903	MARIN	USA	Alcohol Research Programs	000	2	5/29/2008	NON-COMPETING CONTINUATION	$697,630
														Subtotal = $697,630

Issue Date FY: 2007 ( Subtotal = $585,830 )
2007	2007	NEUROBEHAVIORAL RESEARCH, INC	45 GABLE COURT	SAN RAFAEL	CA	94903	MARIN	USA	Alcohol Research Programs	000	1	6/8/2007	NEW	$585,830
														Subtotal = $585,830

Grand Total All Awards = $2,751,075

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EFFECTS OF HEAVY ALCOHOL ABUSE ON ADOLESCENT BRAIN STRUCTURE AND FUNCTION

Award Number: R01AA016303

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/10/2007

PERIOD OF PERFORMANCE END DATE: 05/31/2012

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