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VARIATION IN THE EFFECTS OF ALCOHOL ON LIVER FUNCTION

Award Number: R01AA014041
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2003
PERIOD OF PERFORMANCE END DATE: 07/31/2008

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VARIATION IN THE EFFECTS OF ALCOHOL ON LIVER FUNCTION - DESCRIPTION (provided by applicant): This resubmission is one of a group of Interactive Research Project Grant applications, which have the broad objective of clarifying the role of genes in alcohol dependence and related disorders. Alcohol dependence is a common condition with a substantial genetic component. This application focuses on pre-clinical alcoholic liver disease in a community-based sample and will complement published studies on patients with more advanced disease. The objective is to identify risk factors able to predict which hazardous drinkers are at risk of eventual progression to liver disease. Successful identification of risk factors for alcoholic liver disease may lead to improvements in early identification of people at risk from their drinking, and early intervention to prevent progression to clinical disease. Known risk factors include lifetime quantity of alcohol consumed, and gender (women are more susceptible to alcoholic liver disease than men). The postulated risk factors to be studied are based on a small number of published studies on patients, and on our preliminary work with community samples. They include obesity and related metabolic disorders; iron overload; and allelic variation in a range of candidate genes concerned with alcohol metabolism, inflammatory response within the liver, fatty liver and fibrosis. The specific aims are to test whether the postulated risk factors affect the probability of liver dysfunction in hazardous drinkers, using biochemical liver function tests to detect pre-clinical liver damage. The enzyme liver function tests are abnormal in a substantial proportion (approximately 30-40%) of hazardous drinkers and offer an opportunity for noninvasive testing in large numbers of subjects. Subjects will be drawn from twins and their families who have participated in previous studies of alcohol use and dependence. They will have met DSM-IV criteria for alcohol dependence and/or have reported hazardous levels of alcohol intake in the previous studies. They will provide information on recent alcohol intake, and blood samples will be taken for biochemical testing and as a source of DNA for genotyping. Data will be analyzed using standard methods for twin studies and tests will be included for the effects of postulated phenotypic risk factors, for heritability of liver abnormality conditional on hazardous drinking, and for allelic association at candidate genes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2007 ( Subtotal = $365,546 )
2007	2007	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	BRAMSTON TERRACE HERSTON	BRISBANE				AUS	Alcohol Research Programs	000	5	8/27/2007	NON-COMPETING CONTINUATION	$365,546
														Subtotal = $365,546

Issue Date FY: 2006 ( Subtotal = $365,987 )
2006	2006	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	BRAMSTON TERRACE HERSTON	BRISBANE				AUS	Alcohol Research Programs	000	4	8/30/2006	NON-COMPETING CONTINUATION	$365,987
														Subtotal = $365,987

Issue Date FY: 2005 ( Subtotal = $458,415 )
2005	2005	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	BRAMSTON TERRACE HERSTON	BRISBANE				AUS	Alcohol Research Programs	000	3	8/1/2005	NON-COMPETING CONTINUATION	$458,415
														Subtotal = $458,415

Issue Date FY: 2004 ( Subtotal = $467,325 )
2004	2004	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	BRAMSTON TERRACE HERSTON	BRISBANE				AUS	Alcohol Research Programs	000	2	8/30/2004	NON-COMPETING CONTINUATION	$467,325
														Subtotal = $467,325

Issue Date FY: 2003 ( Subtotal = $407,975 )
2003	2003	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	BRAMSTON TERRACE HERSTON	BRISBANE				AUS	Alcohol Research Programs	000	1	9/1/2003	NEW	$407,975
														Subtotal = $407,975

Grand Total All Awards = $2,065,248

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VARIATION IN THE EFFECTS OF ALCOHOL ON LIVER FUNCTION

Award Number: R01AA014041

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2003

PERIOD OF PERFORMANCE END DATE: 07/31/2008

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