Monday, June 30, 2025 6/30/2025

Chronic Alcohol and Brain Stress Circuit Response

Award Number: R01AA013892
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2003
PERIOD OF PERFORMANCE END DATE: 02/29/2028

Group Awards By:

View Award Description

Chronic Alcohol and Brain Stress Circuit Response - Project Abstract / Summary Alcohol use disorder (AUD) is associated with high relapse risk, and so identifying those most vulnerable to relapse and heavy drinking is critical to improve AUD outcomes. Chronic pain (CP) frequently co-occurs with AUD and promotes pain-related heavy drinking. Previous work showed significant chronic alcohol-related neuroadaptations in stress-related neural and neuroendocrine pathways and high craving that predicted heavy drinking and relapse outcomes. Current preliminary data indicates that AUD patients with CP (AUD+/CP+) and also AUD-/CP+ drinkers report higher cue-induced craving and greater heavy drinking days (HDD), along with specific pain-related insula dysregulation that predicts high cue-induced craving and greater HDD. However, the specific alterations in pain-related neural and biobehavioral circuits that promote pain-related heavy drinking is not known. Based on this preliminary data and previous research, we hypothesize that specific alcohol-related insula neuroadaptations promote higher cue-related alcohol craving and greater pain-related HDD, and that reduction in this specific insula dysregulation and in cue-related alcohol craving with effective standard behavioral treatment will improve pain-related alcohol heavy drinking outcomes in those with AUD+ and CP+ non-AUD drinkers. In a 2 X 2 experimental design with a prospective clinical outcomes phase, men and women with AUD, with/without CP, and non-AUD individuals with/without CP will be studied in two related studies utilizing combined multimethod subjective, neuroendocrine, neural MRI assessments and prospective alcohol use outcomes. The following specific aims are proposed: Aim 1: To examine chronic alcohol- and pain- specific subjective (pain, stress, craving), neural and neuroendocrine responses to visual cue blocks (stress/pain, alcohol, neutral) in AUD (+/-) and CP (+/-) groups. Aim 2: To examine whether specific AUD+ and CP+ neuroadaptations in primary and secondary predictors are associated with prospective, real-world daily alcohol craving, pain and alcohol use outcomes. Aim 3: To evaluate changes in primary and secondary predictors with CBT for AUD and for CP, and whether treatment-related neural, endocrine and subjective responses during fMRI predict treatment-related improvements in daily pain, craving and alcohol use outcomes during the 8-week treatment period. Aim 4: To assess the effects of demographic (sex, age, race) and clinical (trauma, psychiatric history) variables on primary and secondary predictors of AUD and CP comorbidity and on drinking outcomes. Exploratory Aim: To explore whole brain pain-specific structural gray matter volume (GMV) and task-based functional connectivity using connectome-based predictive modeling (CPM) at scan 1, and prediction of changes in pain-related structural GMV and drinking connectomes with CBT treatment. Successful completion of the proposed aims will identify chronic alcohol-related pain-specific neural, subjective and neuroendocrine correlates contributing to increased pain-related alcohol use outcomes, that may then be targeted in treatment development to reduce pain-related drinking outcomes to improve AUD risk and recovery.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $684,360 )
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	18	4/23/2025	NON-COMPETING CONTINUATION	$684,360
														Subtotal = $684,360

Issue Date FY: 2024 ( Subtotal = $694,078 )
2024	2024	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	17	2/7/2024	NON-COMPETING CONTINUATION	$624,669
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	001	17	5/17/2024	NON-COMPETING CONTINUATION	$69,409
														Subtotal = $694,078

Issue Date FY: 2023 ( Subtotal = $672,529 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	16	3/14/2023	COMPETING CONTINUATION	$672,529
														Subtotal = $672,529

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	15	9/12/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	15	4/29/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $611,588 )
2019	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	001	15	9/10/2019	NON-COMPETING CONTINUATION	$46,091
2019	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	15	4/30/2019	NON-COMPETING CONTINUATION	$565,497
														Subtotal = $611,588

Issue Date FY: 2018 ( Subtotal = $605,177 )
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	14	4/26/2018	NON-COMPETING CONTINUATION	$605,177
														Subtotal = $605,177

Issue Date FY: 2017 ( Subtotal = $606,247 )
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	13	4/17/2017	NON-COMPETING CONTINUATION	$545,622
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	001	13	7/27/2017	NON-COMPETING CONTINUATION	$60,625
														Subtotal = $606,247

Issue Date FY: 2016 ( Subtotal = $583,669 )
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	12	4/8/2016	NON-COMPETING CONTINUATION	$583,669
														Subtotal = $583,669

Issue Date FY: 2015 ( Subtotal = $607,886 )
2015	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	11	4/27/2015	COMPETING CONTINUATION	$607,886
														Subtotal = $607,886

Issue Date FY: 2014 ( Subtotal = $0 )
2014	2013	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	10	2/5/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $412,007 )
2013	2013	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	002	10	2/5/2014	NON-COMPETING CONTINUATION	$0
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	001	10	6/11/2013	NON-COMPETING CONTINUATION	$13,290
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	10	12/3/2012	NON-COMPETING CONTINUATION	$398,717
														Subtotal = $412,007

Issue Date FY: 2012 ( Subtotal = $568,190 )
2012	2012	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	9	12/15/2011	NON-COMPETING CONTINUATION	$521,599
2012	2012	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	001	9	2/28/2012	NON-COMPETING CONTINUATION	$46,591
														Subtotal = $568,190

Issue Date FY: 2011 ( Subtotal = $573,638 )
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	001	8	7/11/2011	NON-COMPETING CONTINUATION	$36,504
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	8	12/16/2010	NON-COMPETING CONTINUATION	$537,134
														Subtotal = $573,638

Issue Date FY: 2010 ( Subtotal = $586,557 )
2010	2010	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	7	1/28/2010	NON-COMPETING CONTINUATION	$586,557
														Subtotal = $586,557

Issue Date FY: 2009 ( Subtotal = $446,529 )
2009	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	6	1/16/2009	COMPETING CONTINUATION	$423,029
2009	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	001	6	5/8/2009	COMPETING CONTINUATION	$23,500
														Subtotal = $446,529

Issue Date FY: 2007 ( Subtotal = $339,508 )
2007	2007	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	5	1/24/2007	NON-COMPETING CONTINUATION	$339,508
														Subtotal = $339,508

Issue Date FY: 2006 ( Subtotal = $349,648 )
2006	2006	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	4	3/1/2006	NON-COMPETING CONTINUATION	$349,648
														Subtotal = $349,648

Issue Date FY: 2005 ( Subtotal = $358,063 )
2005	2005	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	3	1/26/2005	NON-COMPETING CONTINUATION	$358,063
														Subtotal = $358,063

Issue Date FY: 2004 ( Subtotal = $357,063 )
2004	2004	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	2	2/16/2004	NON-COMPETING CONTINUATION	$357,063
														Subtotal = $357,063

Issue Date FY: 2003 ( Subtotal = $348,960 )
2003	2003	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	1		NEW	$348,960
														Subtotal = $348,960

Grand Total All Awards = $9,405,697

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Chronic Alcohol and Brain Stress Circuit Response

Award Number: R01AA013892

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2003

PERIOD OF PERFORMANCE END DATE: 02/29/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer