Saturday, October 12, 2024 10/12/2024

Family Health Patterns: A Study Across Generations

Award Number: R01AA012207
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Individuals with a family history of alcoholism (FH+) are 4 to 8 times more likely to develop an alcohol use disorder (AUD) compared to individuals with no such family histories. We developed the Family Health Patterns project to characterize risk-related phenotypic characteristics of FH+ young adults. During our recent funding period, we have identified robust links between increased early life adversity (ELA) in FH+ and their (a) blunted stress reactivity, (b) increased antisocial tendencies, (c) poor affect regulation, and (d) impaired cognitive performance. In our neuroimaging studies, we identified diffusivity changes in frontal white matter tracts in both FH+ young adults and children, suggesting decreased myelination and axon damage in underlying neural circuitry. We interpret these collective findings to suggest that increased ELA in FH+ individuals induces lasting neurobiological changes and consequent behavioral effects that increase AUD risk. To guide the present proposal, we developed a heuristic model of how ELA contributes to risk-related phenotypic characteristics in FH+ persons. We propose that convergent epigenetic and transcriptomic dysregulation of immune genes increase inflammation and immunoreactivity, thereby impairing myelination and/or damaging axons in developing frontal white matter tracts. The resulting impaired communication to and from the prefrontal cortex contributes to phenotypic characteristics of increased antisocial tendencies and poorer affect regulation and cognitive performance, increasing AUD risk. Here we propose to test this model by examining inflammatory gene expression, functional changes in immunoreactivity, and cerebral white matter myelin levels and axon damage markers in FH+ and FH– young adults. We will then examine relationships of these variables with ELA exposure and risk-related phenotypic characteristics. This proposal rigorously builds on our extensive findings on FH+ behavioral and biological phenotypes by testing a novel, overarching model of AUD risk. While extensive preclinical evidence exists illustrating ELA induces long-lasting dysregulation of the immune system and resulting neural and behavioral sequela, our proposal breaks new ground by comprehensively examining these relationships in humans using advanced immunology and multimodal neuroimaging together with in-depth behavioral and clinical assessments.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $612,342 )
2024	2024	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Alcohol Research Programs	000	20	2/12/2024	NON-COMPETING CONTINUATION	$551,110
2024	2024	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Alcohol Research Programs	001	20	5/22/2024	NON-COMPETING CONTINUATION	$61,232
														Subtotal = $612,342

Issue Date FY: 2023 ( Subtotal = $612,342 )
2023	2023	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Alcohol Research Programs	000	19	2/20/2023	NON-COMPETING CONTINUATION	$612,342
														Subtotal = $612,342

Issue Date FY: 2022 ( Subtotal = $612,342 )
2022	2022	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Alcohol Research Programs	000	18	2/23/2022	NON-COMPETING CONTINUATION	$551,104
2022	2022	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Alcohol Research Programs	001	18	6/18/2022	NON-COMPETING CONTINUATION	$61,238
														Subtotal = $612,342

Issue Date FY: 2021 ( Subtotal = $680,224 )
2021	2021	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Alcohol Research Programs	000	17	2/23/2021	COMPETING CONTINUATION	$680,224
														Subtotal = $680,224

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Alcohol Research Programs	000	16	9/11/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $514,115 )
2018	2018	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Alcohol Research Programs	000	16	4/26/2018	NON-COMPETING CONTINUATION	$514,115
														Subtotal = $514,115

Issue Date FY: 2017 ( Subtotal = $518,469 )
2017	2017	UNIVERSITY OF OKLAHOMA	1100 N LINDSAY SCB 219	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Alcohol Research Programs	001	15	7/27/2017	NON-COMPETING CONTINUATION	$51,847
2017	2017	UNIVERSITY OF OKLAHOMA	1100 N LINDSAY SCB 219	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Alcohol Research Programs	000	15	4/10/2017	NON-COMPETING CONTINUATION	$466,622
														Subtotal = $518,469

Issue Date FY: 2016 ( Subtotal = $525,444 )
2016	2016	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	POST OFFICE BOX 26901	OKLAHOMA CITY	OK	73126	OKLAHOMA	USA	Alcohol Research Programs	002	13	7/20/2016	NON-COMPETING CONTINUATION	-$525,444
2016	2016	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	POST OFFICE BOX 26901	OKLAHOMA CITY	OK	73126	OKLAHOMA	USA	Alcohol Research Programs	000	13	4/11/2016	NON-COMPETING CONTINUATION	$525,444
2016	2016	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	POST OFFICE BOX 26901	OKLAHOMA CITY	OK	73126	OKLAHOMA	USA	Alcohol Research Programs	001	14	7/20/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$525,444
2016	2016	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	POST OFFICE BOX 26901	OKLAHOMA CITY	OK	73126	OKLAHOMA	USA	Alcohol Research Programs	003	14	9/1/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2016	2016	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	POST OFFICE BOX 26901	OKLAHOMA CITY	OK	73126	OKLAHOMA	USA	Alcohol Research Programs	004	13	9/1/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $525,444

Issue Date FY: 2015 ( Subtotal = $517,905 )
2015	2015	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	P.O. BOX 26901	OKLAHOMA CITY	OK	73190	OKLAHOMA	USA	Alcohol Research Programs	000	12	4/17/2015	NON-COMPETING CONTINUATION	$517,905
														Subtotal = $517,905

Issue Date FY: 2014 ( Subtotal = $552,647 )
2014	2014	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	P.O. BOX 26901	OKLAHOMA CITY	OK	73190	OKLAHOMA	USA	Alcohol Research Programs	000	11	5/5/2014	COMPETING CONTINUATION	$552,647
														Subtotal = $552,647

Issue Date FY: 2012 ( Subtotal = $340,107 )
2012	2012	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	P.O. BOX 26901	OKLAHOMA CITY	OK	73190	OKLAHOMA	USA	Alcohol Research Programs	000	10	3/9/2012	NON-COMPETING CONTINUATION	$340,107
														Subtotal = $340,107

Issue Date FY: 2011 ( Subtotal = $390,550 )
2011	2011	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	P.O. BOX 26901	OKLAHOMA CITY	OK	73190	OKLAHOMA	USA	Alcohol Research Programs	001	9	7/11/2011	NON-COMPETING CONTINUATION	$22,047
2011	2011	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	P.O. BOX 26901	OKLAHOMA CITY	OK	73190	OKLAHOMA	USA	Alcohol Research Programs	002	9	7/12/2011	SUPPLEMENT FOR EXPANSION	$44,100
2011	2011	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	P.O. BOX 26901	OKLAHOMA CITY	OK	73190	OKLAHOMA	USA	Alcohol Research Programs	000	9	3/15/2011	NON-COMPETING CONTINUATION	$324,403
														Subtotal = $390,550

Issue Date FY: 2010 ( Subtotal = $344,750 )
2010	2010	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	P.O. BOX 26901	OKLAHOMA CITY	OK	73190	OKLAHOMA	USA	Alcohol Research Programs	000	8	3/30/2010	NON-COMPETING CONTINUATION	$344,750
														Subtotal = $344,750

Issue Date FY: 2009 ( Subtotal = $338,668 )
2009	2009	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	P.O. BOX 26901	OKLAHOMA CITY	OK	73190	OKLAHOMA	USA	Alcohol Research Programs	000	7	3/31/2009	NON-COMPETING CONTINUATION	$338,668
														Subtotal = $338,668

Issue Date FY: 2008 ( Subtotal = $328,400 )
2008	2008	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	POST OFFICE BOX 26901	OKLAHOMA CITY	OK	73190	OKLAHOMA	USA	Alcohol Research Programs	000	6	3/17/2008	COMPETING CONTINUATION	$328,400
														Subtotal = $328,400

Issue Date FY: 2005 ( Subtotal = $302,413 )
2005	2005	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	POST OFFICE BOX 26901	OKLAHOMA CITY	OK	73190	OKLAHOMA	USA	Alcohol Research Programs	000	5	6/30/2005	NON-COMPETING CONTINUATION	$302,413
														Subtotal = $302,413

Issue Date FY: 2004 ( Subtotal = $302,413 )
2004	2004	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	POST OFFICE BOX 26901	OKLAHOMA CITY	OK	73190	OKLAHOMA	USA	Alcohol Research Programs	000	4	6/30/2004	NON-COMPETING CONTINUATION	$302,413
														Subtotal = $302,413

Issue Date FY: 2003 ( Subtotal = $302,413 )
2003	2003	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	POST OFFICE BOX 26901	OKLAHOMA CITY	OK	73190	OKLAHOMA	USA	Alcohol Research Programs	000	3	6/25/2003	NON-COMPETING CONTINUATION	$302,413
														Subtotal = $302,413

Issue Date FY: 2002 ( Subtotal = $302,413 )
2002	2002	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	POST OFFICE BOX 26901	OKLAHOMA CITY	OK	73190	OKLAHOMA	USA	Alcohol Research Programs	000	2	6/25/2002	NON-COMPETING CONTINUATION	$302,413
														Subtotal = $302,413

Issue Date FY: 2001 ( Subtotal = $305,351 )
2001	2001	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	POST OFFICE BOX 26901	OKLAHOMA CITY	OK	73190	OKLAHOMA	USA	Alcohol Research Programs	000	1	9/26/2001	NEW	$305,351
														Subtotal = $305,351

Grand Total All Awards = $8,403,308

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Family Health Patterns: A Study Across Generations

Award Number: R01AA012207

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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