Saturday, July 5, 2025 7/5/2025

Identifying neural markers of risk for anxiety in infancy

Award Number: R00MH125878
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2026

Group Awards By:

View Award Description

Identifying neural markers of risk for anxiety in infancy - PROJECT SUMMARY/ABSTRACT Behavioral inhibition (BI), a temperament characterized by fear of novelty, is the best behavioral marker of which children are at risk for anxiety. However, the neurodevelopmental mechanisms that underly the pathway from BI to anxiety remain elusive. Extensive evidence links BI and inhibitory control (IC) processes to the development of anxiety. However, very little evidence has illuminated whether these behaviors are associated with changes in brain connectivity. The goal of the proposed project is to precisely characterize brain networks associated with BI, IC, and their interaction in infancy to illuminate the pathophysiology of anxiety. To do so, during the mentored phase, I will characterize longitudinal changes in brain networks implicated in BI (Aim 1), identify longitudinal changes in resting state functional connectivity that are associated with both BI and IC (Aim 2). Subsequently, during the independent phase (R00), I will replicate and extend this line of work to validate these findings using behavioral measures of BI and IC and identify the moderating contribution that brain networks associated with IC have on the neural correlates of BI (Aim 3). Elucidating the independent and interactive contributions of factors associated with anxiety is essential for generating knowledge for targeted interventions. This research plan will advance my goal of developing an independent funded research program investigating how brain development supports complex social and emotional development. This line of work will target those individuals most at risk for atypical social and emotional outcomes (e.g., those at risk for psychopathology) by charting the precursors to emotional disorders using neuroimaging methods. To effectively lead my future research team, I require intensive training in infant functional magnetic resonance (fMRI) data analysis and longitudinal modeling. To date, my training has provided me with a strong foundation of skills in developmental psychology, infant behavioral assessment, and infant fMRI data collection. My career development plan expands on this skill set to provide essential further training in data-driven approaches for processing fMRI data (e.g., independent components analysis), longitudinal modeling of fMRI data, and toddler fMRI data collection. By engaging in this protected training time, I will enter my independent stage of research well prepared to lead my research team to identify neural markers indicative of high risk for anxiety.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $203,215 )
2025	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Mental Health Research Grants	000	5	4/18/2025	NON-COMPETING CONTINUATION	$203,215
2025	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Mental Health Research Grants	001	5	5/8/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $203,215

Issue Date FY: 2024 ( Subtotal = $245,363 )
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Mental Health Research Grants	003	4	8/16/2024	NON-COMPETING CONTINUATION	$24,537
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Mental Health Research Grants	002	4	3/20/2024	NON-COMPETING CONTINUATION	$220,826
2024	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Mental Health Research Grants	001	3	12/14/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$248,999
2024	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Mental Health Research Grants	000	2	12/12/2023	EXTENSION WITH OR WITHOUT FUNDS	-$248,999
														Subtotal = $245,363

Issue Date FY: 2023 ( Subtotal = $248,999 )
2023	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Mental Health Research Grants	000	2	5/12/2023	EXTENSION WITH OR WITHOUT FUNDS	$248,999
2023	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Mental Health Research Grants	001	2	5/16/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $248,999

Grand Total All Awards = $697,577

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Identifying neural markers of risk for anxiety in infancy

Award Number: R00MH125878

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer