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Substance P-Mediated Enhancement of Salience for Cues Predicting Aversive Outcomes

Award Number: R00MH123673
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Substance P-Mediated Enhancement of Salience for Cues Predicting Aversive Outcomes - Project Summary Maladaptive fear exacerbates responses to aversive stimuli and enhances stress and anxiety. However, brain mechanisms that drive these aversive responses and enhance salience of aversive stimuli are not known. The excitatory peptide substance P produces a spatially restricted, glutamatergic long-term potentiation on a subset of Nucleus Accumbens core neurons that are known to promote aversion. Furthermore, this long-term potentiation occurs in the Nucleus Accumbens core following fear conditioning and can be suppressed by blocking substance P signaling. Glutamatergic inputs, particularly limbic inputs, to this sub-region are among several brain systems that encode salience to cues, suggesting substance P may drive integration of salience-related signals on these cells to promote learning about aversive stimuli that proceeds behavioral action. Using a multi-level approach including slice electrophysiology, optogenetics, and fiber photometry, this project aims to understand how substance P-mediated potentiation of saliencerelated inputs to the nucleus accumbens core promotes salience to cues predicting aversive outcomes and aims to develop brain stimulation paradigms to suppress fear responding.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $239,237 )
2024	2024	UNIVERSITY OF SOUTH CAROLINA	1600 HAMPTON ST	COLUMBIA	SC	29208	RICHLAND	USA	Mental Health Research Grants	000	4	5/7/2024	NON-COMPETING CONTINUATION	$239,237
														Subtotal = $239,237

Issue Date FY: 2023 ( Subtotal = $246,266 )
2023	2023	UNIVERSITY OF SOUTH CAROLINA	1600 HAMPTON ST # 414	COLUMBIA	SC	29208	RICHLAND	USA	Mental Health Research Grants	000	3	5/10/2023	NON-COMPETING CONTINUATION	$246,266
														Subtotal = $246,266

Issue Date FY: 2022 ( Subtotal = $249,000 )
2022	2022	UNIVERSITY OF SOUTH CAROLINA	1600 HAMPTON ST # 414	COLUMBIA	SC	29208	RICHLAND	USA	Mental Health Research Grants	000	2	8/8/2022	EXTENSION WITH OR WITHOUT FUNDS	$249,000
														Subtotal = $249,000

Grand Total All Awards = $734,503

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Substance P-Mediated Enhancement of Salience for Cues Predicting Aversive Outcomes

Award Number: R00MH123673

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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