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Brain-wide neural population dynamics during decision making and learning

Award Number: R00MH121533
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/06/2023
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Brain-wide neural population dynamics during decision making and learning - Project Summary / Abstract Decision-making requires populations of neurons in the brain to collectively process sensory evidence and select appropriate behavioral responses. Neural population dynamics (NPDs), which describe how the responses of a population of individual neurons unfold over time, can provide an insightful view into these decision processes. Much is known about how individual neurons respond in select decision making tasks. However, little is known about how populations of neurons dynamically perform decision computations, and how resulting NPDs within a brain area are structured across many decision-making tasks. Shared features in NPDs across many tasks could indicate unifying neural mechanisms of computation that underlie the multi-functionality of a given neural circuit. This proposal aims to uncover the details and structure of these decision-related NPDs in human and nonhuman primate dorsal premotor cortex, an area tightly linked to both the function and dysfunction of decision making. Particular attention will be devoted to examining how NPDs are organized across multiple decision-making tasks and how those NPDs emerge during learning of new tasks. During the K99 phase, novel analytical tools will be developed for extracting NPDs from simultaneously recorded neural population activity and, importantly, for providing interpretable links between NPDs and their role in decision-related neural computation. With the goal of identifying unifying principles of decision-related computation, large-scale analyses will then integrate existing and newly collected neurophysiological datasets involving multiple decision-making tasks performed by humans and nonhuman primates. During the R00 phase, the proposed research will pivot toward understanding how NPDs emerge during learning to make new types of decisions. The proposal postulates that the ease, speed, and efficacy of learning all hinge on the extent by which critical neural circuits can leverage pre-existing neural mechanisms of computation. These concepts will be tested in collaborative human and nonhuman primate neu- rophysiological experiments, with guidance provided by interrogations of artificial neural networks posed with similar decision-related learning tasks. Upon completion, the proposed research will provide new fundamental knowledge concerning i) the multi-functional and adaptive role of premotor cortex across many decision-making tasks and ii) unifying principles of neural computation that support this flexibility. Better understanding decision- related circuits and their neural mechanisms could ultimately elucidate the basis for the numerous psychiatric disorders that impair decision making, which could eventually lead to improved diagnosis and treatment of these debilitating conditions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	000	5	12/10/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $248,965 )
2025	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	001	5	3/11/2025	NON-COMPETING CONTINUATION	-$37,344
2025	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	000	5	3/7/2025	NON-COMPETING CONTINUATION	$248,965
2025	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	002	5	9/17/2025	NON-COMPETING CONTINUATION	$37,344
														Subtotal = $248,965

Issue Date FY: 2024 ( Subtotal = $248,965 )
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	001	4	7/16/2024	NON-COMPETING CONTINUATION	$24,897
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	000	4	1/24/2024	NON-COMPETING CONTINUATION	$224,068
														Subtotal = $248,965

Issue Date FY: 2023 ( Subtotal = $257,056 )
2023	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	001	3	6/26/2023	EXTENSION WITH OR WITHOUT FUNDS	$8,091
2023	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	000	3	2/6/2023	EXTENSION WITH OR WITHOUT FUNDS	$248,965
														Subtotal = $257,056

Grand Total All Awards = $754,986

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Brain-wide neural population dynamics during decision making and learning

Award Number: R00MH121533

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/06/2023

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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