Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

The Role of Kit Signaling in Cerebellar Development

Award Number: R00MH110665
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2019
PERIOD OF PERFORMANCE END DATE: 01/31/2023

Group Awards By:

View Award Description

The Role of Kit Signaling in Cerebellar Development - Modified Project Summary/Abstract Section This project proposes the transition from the K99 to the R00 phase; it is accompanied by the move to a new (R1 level) institution: the Grand Rapids Research Center of Michigan State University, where I have accepted a tenure-track assistant professor position (after NIMH approval of the offer). There are no major changes in the nature of the research proposed versus the K99 phase, only technical differences in the experimental design and expansion of studies already completed. My long-term goal is to inform the etiology of pediatric mental health disorders by determining the normal role of candidate genes in brain development. The near-term goal of this project is to investigate a specific gene: the receptor tyrosine kinase, Kit (herein KitR). Mutations in KitR have been identified in cases of intellectual disability and autism. KitR is abundantly expressed in the brain, but little is known about how KitR may regulate brain development. I propose to address this gap using the mouse cerebellum as a model system due to the high and similar expression of KitR in human versus mouse cerebella and due to the experimental and genetic tractability of mice. Within the cerebellum, Kit Ligand (KitL) is expressed post-synaptically by Purkinje cells (PCs), while KitR is expressed pre-synaptically by Molecular Layer Interneurons (MLIs). I hypothesize that Kit signaling regulates cerebellar development by the mechanism that target-derived KitL attracts KitR expressing neurons to migrate and form synapses. Specific Aim 1 is to test the hypothesis that PC KitL attracts the migration and innervation of MLIs. Specific Aim 2 is to test the hypothesis that MLI KitR is required for the normal innervation of PCs. Specific Aim 3 is to determine by what effectors KitR regulates neuronal migration and synaptogenesis. These Aims will be accomplished by viral and transgenic strategies to knockout, mis-express, or reconstitute endogenous and mutant forms of KitL or KitR in vivo (mouse brain). The impacts on migration, maturation, and connectivity of KitL/R manipulated neurons will then be assayed by microscopy and electrophysiology. These studies will serve NIMH Research Priority 1.1A: to "Determine the molecular, cellular, and systems components underlying brain connectivity."


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Mental Health Research Grants	000	5	11/30/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $249,000 )
2021	2021	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Mental Health Research Grants	000	5	1/25/2021	NON-COMPETING CONTINUATION	$249,000
														Subtotal = $249,000

Issue Date FY: 2020 ( Subtotal = $249,000 )
2020	2020	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Mental Health Research Grants	000	4	2/12/2020	NON-COMPETING CONTINUATION	$249,000
														Subtotal = $249,000

Issue Date FY: 2019 ( Subtotal = $252,802 )
2019	2019	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Mental Health Research Grants	000	3	4/26/2019	EXTENSION WITH OR WITHOUT FUNDS	$248,999
2019	2019	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Mental Health Research Grants	001	3	6/4/2019	EXTENSION WITH OR WITHOUT FUNDS	$3,803
														Subtotal = $252,802

Grand Total All Awards = $750,802

Top

All Categories

About

Search

Reports

Data Submission

Award Information

The Role of Kit Signaling in Cerebellar Development

Award Number: R00MH110665

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2019

PERIOD OF PERFORMANCE END DATE: 01/31/2023

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer