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Neuroscientific Exploration of Cultural Protective Factors in American Indians

Award Number: R00MD015736
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/27/2020
PERIOD OF PERFORMANCE END DATE: 04/29/2025

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Neuroscientific Exploration of Cultural Protective Factors in American Indians - PROJECT SUMMARY American Indian (AI) populations have had the largest increase in suicide rates of any ethnic group in that past decade and have high rates of mental health concerns such as post-traumatic stress, substance use, anxiety, and mood disorders. However, previous research and preliminary analyses demonstrated that AIs actually display lower levels of mental health concerns than broader populations when accounting for increased levels of risk factors, (e.g., trauma exposure). Extant literature indicates that factors associated with AI culture are protective against poor mental health. Yet, little is known about how cultural factors (e.g., enculturation, social support) play a protective role. There are no published studies examining neural underpinnings of the protective role of AI cultural factors. Filling this gap is a critical step in supporting an experimental therapeutics approach to developing culturally informed prevention and intervention efforts. Cognitive control is a neurocognitive function that is implicated across numerous psychiatric disorders, can be assessed with validated behavioral and neuroimaging tasks, and has been well-delineated in regard to underlying neural circuitry. The aims of the proposal are to (a) determine whether cultural protective factors relate to behavioral and neural indicators of cognitive control, as measured during electroencephalography and functional magnetic resonance imaging and (b) develop an experimental, cultural identification paradigm to serve as the basis for future culturally-informed neuroscientific research and intervention/prevention efforts. A community based participatory research (CBPR) framework will be used to recruit participants who have completed multimodal neural and behavioral indicators of cognitive control, clinical interviews, self-report measures of psychopathology symptoms and global functioning as part of a previous study. They will complete self-report measures of enculturation, social support, global functioning and a cultural enhancement induction paradigm developed using a CBPR framework. These data will provide an essential foundation for developing culturally informed, evidence-based intervention and prevention efforts aimed at reducing the mental health disparities among AIs. The proposed training plan will expand Dr. White expertise in neuroscientific mechanisms of cognitive control through mentorship, coursework, and hands-on training in advanced statistical methods, multimodal (EEG/fMRI) neuroimaging, clinical neuroscience, and culturally informed research. He has assembled a team of mentors well suited to provide the required diversity of expertise he needs to achieve independence. Dr. Martin Paulus will provide expertise neuroimaging and advanced data analytic expertise. Dr. Aupperle will bring extensive experience related to neuroimaging and clinically relevant neuroscience approaches. Dr. Lowe will provide expertise and experiences in AI culturally informed research. The training and associated research will be conducted at LIBR, a state-of-the-art institute dedicated to neuroimaging research aimed at developing more effective treatments for neuropsychiatric disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $156,271 )
2025	2025	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Minority Health and Health Disparities Research	001	5	11/29/2024	NON-COMPETING CONTINUATION	$156,271
2025	2025	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Minority Health and Health Disparities Research	002	5	4/29/2025	NON-COMPETING CONTINUATION	$0
2025	2025	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Minority Health and Health Disparities Research	003	5	5/20/2025	NON-COMPETING CONTINUATION	$0
2025	2024	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Minority Health and Health Disparities Research	000	4	11/28/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $156,271

Issue Date FY: 2024 ( Subtotal = $244,226 )
2024	2024	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Minority Health and Health Disparities Research	000	4	11/6/2023	NON-COMPETING CONTINUATION	$219,803
2024	2024	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Minority Health and Health Disparities Research	001	4	5/24/2024	NON-COMPETING CONTINUATION	$24,423
														Subtotal = $244,226

Issue Date FY: 2023 ( Subtotal = $248,156 )
2023	2023	LAUREATE INSTITUTE FOR BRAIN RESEARCH	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Minority Health and Health Disparities Research	002	3	2/16/2023	EXTENSION WITH OR WITHOUT FUNDS	$29,653
2023	2023	LAUREATE INSTITUTE FOR BRAIN RESEARCH	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Minority Health and Health Disparities Research	000	3	11/15/2022	EXTENSION WITH OR WITHOUT FUNDS	$218,503
2023	2023	LAUREATE INSTITUTE FOR BRAIN RESEARCH	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Minority Health and Health Disparities Research	001	3	1/13/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $248,156

Grand Total All Awards = $648,653

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Neuroscientific Exploration of Cultural Protective Factors in American Indians

Award Number: R00MD015736

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/27/2020

PERIOD OF PERFORMANCE END DATE: 04/29/2025

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