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A Multilevel Approach to Cardiovascular Health in African American Breast Cancer Survivors: from Neighborhoods to Metabolomics

Award Number: R00MD013300
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/14/2018
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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A Multilevel Approach to Cardiovascular Health in African American Breast Cancer Survivors: from Neighborhoods to Metabolomics - ABSTRACT This application will provide the candidate, Dr. Qin, with needed training and research experiences for her to grow into an independent investigator in cancer health disparities. Dr. Qin’s long-term career goal is to integrate multilevel and transdisciplinary components into cancer epidemiology research that will increase the understanding of multilevel modifiable factors affecting cancer health, especially in minority cancer populations, and will ultimately reduce cancer health disparities. African American (AA) breast cancer (BrCa) survivors have worse cardiovascular health (CVH, e.g., obesity, diabetes, unhealthy diet) compared to their white counterparts, which contributes to sizable racial disparities in BrCa mortality. Although the disproportionate burden of poor CVH among AA BrCa survivors is hypothesized to result from multilevel determinants ranging from neighborhood social and built environments to biological and molecular pathways, most studies have examined either biological or behavioral factors, neglecting the influence from neighborhood social and built environments, and cross-level associations and mechanisms. Thus, conceptualized on the NIMHD research framework, the goal of the proposed study is to investigate multilevel modifiable factors affecting BrCa survivorship (with a targeted focus on CVH) and survival among AA women. To achieve this goal, Dr. Qin will utilize the Women’s Circle of Health Follow-Up Study (WCHFS), an existing and ongoing population-based longitudinal study of AA breast cancer survivors, for four specific aims. In Aim 1, she will integrate neighborhood environment measures with WCHFS to enrich this individual-level survey and medical record data. In Aims 2 and 3, she will investigate specific modifiable neighborhood factors influencing CVH and survival of AA BrCa patients. In Aim 4, she will examine the underlying biological mechanisms between CVH and both BrCa-specific and overall survival through serum metabolomic profiling. Results from the proposed study may improve BrCa outcomes among AA women in two ways. First, in addition to a much better risk stratification of the BrCa population, investigating potentially modifiable neighborhood factors can inform stakeholder efforts in developing evidence-based, wide-reaching strategies such as land use regulations, zoning, and street design. Second, evaluating metabolomic signatures that medicate CVH and BrCa survival will have great potential to advance the use of biomarkers to monitor CVH and to guide pharmacologic interventions that will improve BrCa survival. Dr. Qin will develop additional expertise in multilevel and geospatial methods, cancer health disparities in survivorship and survival, and cancer metabolism and metabolomics through structured training and career development activities and didactic mentoring from an interdisciplinary team. The proposed training and research together with protected time are crucial to facilitate Dr. Qin’s transition into an independent investigator in cancer health disparities with expertise in conducting multilevel epidemiological studies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	195 LITTLE ALBANY ST	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Minority Health and Health Disparities Research	000	5	9/29/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	195 LITTLE ALBANY ST	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Minority Health and Health Disparities Research	000	5	5/29/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $239,535 )
2022	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	195 LITTLE ALBANY ST	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Minority Health and Health Disparities Research	000	5	5/8/2022	NON-COMPETING CONTINUATION	$239,535
														Subtotal = $239,535

Issue Date FY: 2021 ( Subtotal = $246,587 )
2021	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	195 LITTLE ALBANY ST	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Minority Health and Health Disparities Research	002	4	5/17/2021	NON-COMPETING CONTINUATION	$0
2021	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	195 LITTLE ALBANY ST	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Minority Health and Health Disparities Research	000	4	4/26/2021	NON-COMPETING CONTINUATION	$246,587
2021	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	195 LITTLE ALBANY ST	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Minority Health and Health Disparities Research	001	3	5/17/2021	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $246,587

Issue Date FY: 2020 ( Subtotal = $262,909 )
2020	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	195 LITTLE ALBANY ST	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Minority Health and Health Disparities Research	000	3	5/1/2020	EXTENSION WITH OR WITHOUT FUNDS	$248,817
2020	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	195 LITTLE ALBANY ST	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Minority Health and Health Disparities Research	001	3	9/23/2020	EXTENSION WITH OR WITHOUT FUNDS	$14,092
														Subtotal = $262,909

Grand Total All Awards = $749,031

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A Multilevel Approach to Cardiovascular Health in African American Breast Cancer Survivors: from Neighborhoods to Metabolomics

Award Number: R00MD013300

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/14/2018

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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