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High-performance deep neural networks for medical image analysis

Award Number: R00LM014309
ORGANIZATION: NATIONAL LIBRARY OF MEDICINE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2025
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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High-performance deep neural networks for medical image analysis - Project Summary Lack of transparency and trustworthiness of deep neural networks (DNNs) has long been recognized as a major drawback of the technology, hindering its widespread acceptance in many practical applications. The objective of this project is to establish a novel contrastive feature analysis (CFA) framework for reliable visualization of the high dimensional feature space and effective design of high-performance DNNs for medical image analysis. We hypothesize that CFA-based feature visualization will enable us to quantify the quality of the feature space at different layers during training/testing of a DNN and empower us with an effective tool to prune the network architecture for enhanced performance. Specifically, we will (1) develop an efficient visualization technique CFA for high dimensional feature data, 2) apply the CFA visualization framework to automatically refine DNN architecture for improved performance, and 3) demonstrate the potential of CFA in solving clinical problems. Successful completion of the project will enable us to analyze the feature data reliably and quantify the quality of the feature space at different layers of a DNN. The study also promises to provide high-performance DNNs for medical image analysis to substantially improve the AI-based diagnosis, prognosis and treatment planning of different diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $249,000 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Medical Library Assistance	000	3	4/15/2025	EXTENSION WITH OR WITHOUT FUNDS	$249,000
														Subtotal = $249,000

Grand Total All Awards = $249,000

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High-performance deep neural networks for medical image analysis

Award Number: R00LM014309

ORGANIZATION: NATIONAL LIBRARY OF MEDICINE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2025

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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