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Adaptation and pilot testing of a couples-based intervention to prevent perinatal depression in rural India

Award Number: R00HD114849
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2026
PERIOD OF PERFORMANCE END DATE: 07/31/2029

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Adaptation and pilot testing of a couples-based intervention to prevent perinatal depression in rural India - PROJECT SUMMARY (See instructions): Perinatal depression (PND) affects approximately 25% of women in India, with rates as high as 60% antenatally in preliminary data from the Vadu Health and Demographic Surveillance System (HDSS) — a population-based surveillance platform covering 220,000 individuals across 22 villages in Pune district, Maharashtra. Untreated PND has cascading consequences for the entire family unit, including diminished mother-infant bonding, low birth weight, and long-term child developmental impairments. In India, where marital and family dynamics are primary determinants of women’s mental health and health-seeking, couples-based approaches that engage husbands as active treatment partners are theoretically compelling yet entirely absent from South Asia. This R00 will adapt and pilot test JODI (Joint Outreach for Depression and gender Inequity), the first couples-based PND treatment intervention designed for lay counselor delivery in an LMIC, developed during the K99 phase through a global systematic review, formative qualitative research with perinatal couples in rural Rajasthan, and series of stakeholder intervention development steps. JODI integrates the Communal Coping Model and Bodenmann’s Systemic Transactional Model with a Gender Transformative Framework to address the structural and relational drivers of PND through dyadic coping skill-building and gender norm examination across weekly sessions delivered by trained female lay counselors. In Aim 1, JODI will be adapted for the Maharashtra context through stakeholder consultations and theater testing in KEM Hospital Research Centre (KEMRC), Pune. In Aim 2, a hybrid type 1 implementation-effectiveness pilot RCT (N=100 couples) at the Vadu HDSS will assess feasibility, acceptability, and preliminary efficacy of JODI versus enhanced usual care, guided by Proctor’s framework. Findings will directly inform a future R01 full-scale multisite efficacy trial and, if effective, position JODI as a scalable, low-cost model for addressing PND across South Asia and similar resource-limited settings.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $249,000 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Child Health and Human Development Extramural Research	001	3	7/1/2026	SUPPLEMENT FOR EXPANSION	$44,794
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Child Health and Human Development Extramural Research	000	3	6/22/2026	EXTENSION WITH OR WITHOUT FUNDS	$204,206
														Subtotal = $249,000

Grand Total All Awards = $249,000

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Adaptation and pilot testing of a couples-based intervention to prevent perinatal depression in rural India

Award Number: R00HD114849

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2026

PERIOD OF PERFORMANCE END DATE: 07/31/2029

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