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Maternal Childhood Maltreatment-Influenced Prenatal Programming of Early Brain-Behavior and Risk for Future Psychopathology

Award Number: R00HD110939
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2026
PERIOD OF PERFORMANCE END DATE: 02/28/2029

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Maternal Childhood Maltreatment-Influenced Prenatal Programming of Early Brain-Behavior and Risk for Future Psychopathology - The R00 Pathway to Independence Award will establish the applicant's independent research program as a tenure track faculty member in the Departments of Psychiatry and Obstetrics, Gynecology and Reproductive Science (OBGYN) at the Icahn School of Medicine at Mount Sinai (ISMMS). The Developmental Origins of Health and Disease (DOHaD) framework is supported by a robust literature that provides evidence for the role of environmental exposures in shaping brain and behavior development through prenatal programming. Maternal childhood maltreatment has been associated with both maternal prenatal mental health and infant emotion regulation outcomes; however, most known transmission pathways are behavioral, with limited evidence for biological transmission. Well-established behavioral pathways are through maternal mental health and parenting sensitivity influencing infant emotion regulation and mother-infant interactions. Emerging evidence supports maternal childhood maltreatment effects on infant outcomes through biological pathways such as in utero programming of brain development. Despite the


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $249,000 )
2026	2026	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Child Health and Human Development Extramural Research	000	3	2/27/2026	EXTENSION WITH OR WITHOUT FUNDS	$249,000
														Subtotal = $249,000

Grand Total All Awards = $249,000

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Maternal Childhood Maltreatment-Influenced Prenatal Programming of Early Brain-Behavior and Risk for Future Psychopathology

Award Number: R00HD110939

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2026

PERIOD OF PERFORMANCE END DATE: 02/28/2029

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