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Machine learning methods to assess risk for prenatal and neonatal iron deficiency anemia from maternal stress exposure

Award Number: R00HD109373
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Machine learning methods to assess risk for prenatal and neonatal iron deficiency anemia from maternal stress exposure - PROJECT SUMMARY This K99 application aims to determine biological and behavioral pathways by which maternal psychosocial stress in pregnancy impacts risk for maternal and infant iron deficiency anemia (IDA). IDA is one of the most common causes of anemia worldwide, and around 20% of women in the US experience a stressful life event throughout their pregnancy. Due to the increased iron demands of pregnancy, pregnancy itself poses a significant risk of IDA, especially for low-income and racially- and ethnically-minoritized women. IDA increases the risk of adverse pregnancy outcomes and can negatively impact the iron status of the neonate that may cause irreversible harm to neurodevelopment. There is growing concern that oral vitamin supplementation might not be enough to counteract the risks of IDA in the context of systemic inflammation, including inflammation produced by chronic psychosocial stress and subsequent neuroendocrine dysregulation. Maternal psychosocial stress has been associated with infant iron status previously, but the potential biological mechanisms are not yet characterized despite the


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,690 )
2025	2024	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	3	10/9/2024	EXTENSION WITH OR WITHOUT FUNDS	$0
2025	2024	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Child Health and Human Development Extramural Research	001	3	12/26/2024	EXTENSION WITH OR WITHOUT FUNDS	$3,690
														Subtotal = $3,690

Issue Date FY: 2024 ( Subtotal = $248,957 )
2024	2024	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	3	8/7/2024	EXTENSION WITH OR WITHOUT FUNDS	$248,957
														Subtotal = $248,957

Grand Total All Awards = $252,647

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Machine learning methods to assess risk for prenatal and neonatal iron deficiency anemia from maternal stress exposure

Award Number: R00HD109373

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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