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Mapping inter-cellular trophoblast-decidual signaling to its effects on invasion related maternal-fetal

Award Number: R00HD105973
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Mapping inter-cellular trophoblast-decidual signaling to its effects on invasion related maternal-fetal - The transcriptional regulation and intercellular signaling at the maternal fetal interface impacts a number of pregnancy related pathologies. Specifically, the endometrial cells, such as the endometrial stromal trophoblasts undergo transcriptional regulation of distinct mechanistic programs that affect their permissiveness to placental invasion. Dysregulation of this placental invasion can underly the etiology of invasion related maternal fetal diseases (IMFDs) such as pre-eclampisa, fetal growth restriction, and placenta previa. This project will study the evolution of transcriptional regulatory elements underlying tissue mechanical integrity in the endometrium. Using machine learning and statistical models, combined with comparative genomics and computational regulatory element prediction, we will prioritize putative elements that functionally control endometrial tissue integrity in the face of placental invasion. In addition, the mechanistic insights thus gained will be combined with a data-centric approach to develop a prognostic model to relate individual transcriptional profiles of endometrial cells to IMFD disease risk.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $249,000 )
2025	2025	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Child Health and Human Development Extramural Research	000	4	9/2/2025	EXTENSION WITH OR WITHOUT FUNDS	$249,000
														Subtotal = $249,000

Grand Total All Awards = $249,000

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Mapping inter-cellular trophoblast-decidual signaling to its effects on invasion related maternal-fetal

Award Number: R00HD105973

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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